Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer-Reference-Cited by-同舟云学术

Role of m6A modification in regulating the PI3K/AKT signaling pathway in cancer

Published:2023-11-01 Issue:1 Volume:21 Page:
ISSN:1479-5876
Container-title:Journal of Translational Medicine
language:en
Short-container-title:J Transl Med

Author:

Liu Jie,Gu Xinyu,Guan Zhenjie,Huang Di,Xing Huiwu^ORCID,Zheng Lian

Abstract

AbstractThe phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a crucial role in the pathogenesis of cancer. The dysregulation of this pathway has been linked to the development and initiation of various types of cancer. Recently, epigenetic modifications, particularly N6-methyladenosine (m6A), have been recognized as essential contributors to mRNA-related biological processes and translation. The abnormal expression of m6A modification enzymes has been associated with oncogenesis, tumor progression, and drug resistance. Here, we review the role of m6A modification in regulating the PI3K/AKT pathway in cancer and its implications in the development of novel strategies for cancer treatment.

Funder

Henan Provincial Medical Science and Technology Research Plan

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://link.springer.com/content/pdf/10.1186/s12967-023-04651-0.pdf

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