Computer-based cognitive tests and cerebral pathology among Japanese older adults
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Published:2023-04-10
Issue:1
Volume:23
Page:
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ISSN:1471-2318
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Container-title:BMC Geriatrics
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language:en
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Short-container-title:BMC Geriatr
Author:
Shimada Hiroyuki,Makino Keitaro,Kato Takashi,Ito Kengo
Abstract
Abstract
Background
This study aimed to identify the appropriate computer-based cognitive tests and cut-off values for estimating amyloid burden in preclinical Alzheimer’s disease drug trials.
Methods
Data from 103 older individuals, who underwent 18F-florbetapir positron emission tomography and cognitive testing, were analyzed. Cognitive tests evaluated word list memory (immediate recognition and delayed recall), attention (Trail Making Test-part A), executive function (Trail Making Test-Part B), and processing speed (Digit Symbol Substitution Test [DSST]).
Results
The Aβ burden was significantly associated with word list memory (odds ratio [OR] = 0.42, 95% confidence interval [CI], 0.19–0.91) and DSST (OR = 0.35; 95% CI, 0.14–0.85). Positive predictive value and number needed to screen at a cut-off of 1.5 SD were better for word list memory and DSST among predictive values.
Conclusions
The computer-based memory and processing speed tests have the potential to reduce failure rates while screening individuals with Aβ accumulation in community settings.
Funder
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology
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