Traumatic life events and risk for dementia: a systematic review and meta-analysis

Author:

Severs Emilia,James Tiffeny,Letrondo Pilar,Løvland Lise,Marchant Natalie L.,Mukadam Naaheed

Abstract

Abstract Objectives To systematically review the association between traumatic life events (TLE) and dementia risk. Design Systematic review and meta-analysis. Data sources APA, PsychINFO, Embase and MEDLINE from their inception to 29.05.21 and updated on 20.04.22. Eligibility criteria for selecting studies Original research articles published in peer reviewed journals examining the association between TLE and all cause dementia in individuals aged 60 and over. Two researchers independently assessed the risk of bias using the Newcastle–Ottawa Scale. We conducted a generic inverse variance random effects meta-analysis to provide an overall estimate of TLE impact on dementia risk. Main outcome measures Risk, odds and hazards ratios relating to dementia risk. Results Initially, 3,487 studies were retrieved in the search and seven studies were included in the meta-analysis with data being used from 276,570 participants. TLE were associated with increased dementia risk. Trauma in general had a pooled HR of 1.21, (95% CI 1.03, 1.43, P = 0.0001). War/ Holocaust trauma and childhood trauma were also associated with increased dementia risk (HR = 1.28 (95% CI 1.01–1.63, P = 0.02) and HR = 1.76 (95% CI 1.17–2.64, P = 0.007) respectively). Conclusions We have found an association between TLE and dementia risk. Future research exploring the dimensions of TLE and individual level factors are needed to better understand the relationship between TLE and dementia. Trial Registration PROSPERO CRD42021253090.

Publisher

Springer Science and Business Media LLC

Subject

Geriatrics and Gerontology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Research Roundup;British Journal of Neuroscience Nursing;2023-12-02

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3