Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus

Author:

Ingen-Housz-Oro S.ORCID,Schmidt V.,Ameri M. M.,Abe R.,Brassard A.,Mostaghimi A.,Paller A. S.,Romano A.,Didona B.,Kaffenberger B. H.,Ben Said B.,Thong B. Y. H.,Ramsay B.,Brezinova E.,Milpied B.,Mortz C. G.,Chu C. Y.,Sotozono C.,Gueudry J.,Fortune D. G.,Dridi S. M.,Tartar D.,Do-Pham G.,Gabison E.,Phillips E. J.,Lewis F.,Salavastru C.,Horvath B.,Dart J.,Setterfield J.,Newman J.,Schulz J. T.,Delcampe A.,Brockow K.,Seminario-Vidal L.,Jörg L.,Watson M. P.,Gonçalo M.,Lucas M.,Torres M.,Noe M. H.,Hama N.,Shear N. H.,O’Reilly P.,Wolkenstein P.,Romanelli P.,Dodiuk-Gad R. P.,Micheletti R. G.,Tiplica G. S.,Sheridan R.,Rauz S.,Ahmad S.,Chua S. L.,Flynn T. H.,Pichler W.,Le S. T.,Maverakis E.,Walsh S.,French L. E.,Brüggen M. C.

Abstract

Abstract Background Long-term sequelae are frequent and often disabling after epidermal necrolysis (Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)). However, consensus on the modalities of management of these sequelae is lacking. Objectives We conducted an international multicentric DELPHI exercise to establish a multidisciplinary expert consensus to standardize recommendations regarding management of SJS/TEN sequelae. Methods Participants were sent a survey via the online tool “Survey Monkey” consisting of 54 statements organized into 8 topics: general recommendations, professionals involved, skin, oral mucosa and teeth, eyes, genital area, mental health, and allergy workup. Participants evaluated the level of appropriateness of each statement on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). Results were analyzed according to the RAND/UCLA Appropriateness Method. Results Fifty-two healthcare professionals participated. After the first round, a consensus was obtained for 100% of 54 initially proposed statements (disagreement index < 1). Among them, 50 statements were agreed upon as ‘appropriate’; four statements were considered ‘uncertain’, and ultimately finally discarded. Conclusions Our DELPHI-based expert consensus should help guide physicians in conducting a prolonged multidisciplinary follow-up of sequelae in SJS-TEN.

Funder

ERN-skin

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Genetics (clinical),General Medicine

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3