Author:
Adhi Mehreen,Farooq Asma,Hamid Syed Ali,Hasan Rabia,Mamji Salman,Baloch Akhtar Ali
Abstract
Abstract
Introduction
We report a case of sero-negative celiac disease in Pakistan.
Case presentation
A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms.
Conclusion
Negative serology should not rule out celiac disease; intestinal biopsy should be performed if there is strong clinical suspicion.
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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1. Seronegative Celiac Disease;Diagnosis and Management of Gluten-Associated Disorders;2020-12-04
2. Dysphagia as a Presentation of Celiac Disease;ACG Case Reports Journal;2020-04
3. Coeliac disease in Pakistan: A bibliographic review of current research status;Journal of the Pakistan Medical Association;2019