Author:
Liu Yang,Zhang PengPeng,Li JunHui,Li Hao,Zhou Chen,Zhang Yu,Ming YingZi
Abstract
Abstract
Background
Liver fibrosis is thought to have a close relationship with lipid profile. The possible association between lipids and liver fibrosis of different etiologies has been widely explored. However, the association between lipids and liver fibrosis in patients infected with Schistosoma japonicum remains unclear. In the present study we undertook a preliminary exploration of the association between lipid profile and liver fibrosis, and developed a new predictive index for liver fibrosis in S. japonicum-infected patients.
Methods
A total of 1503 patients diagnosed with S. japonicum at Xiangyue Hospital, China were enrolled in this retrospective study. The patients were divided into two groups, i.e., those with and those without liver fibrosis, by two experienced schistosomiasis specialists, according to the results of liver ultrasound examination. Demographic, clinical, and laboratory data were collected. Multivariable logistic models were used to estimate the independent associations between lipid profile and liver fibrosis. Receiver operating characteristic (ROC) curves were used to assess the discriminative ability of the new index in predicting liver fibrosis in patients with schistosomiasis.
Results
Logistic regression analysis showed that high-density lipoprotein (HDL) [adjusted odds ratio (aOR), 95% confidence interval (CI) 7.334, 5.051–10.649; P < 0.001], low-density lipoprotein (LDL) (aOR, 95% CI 0.434, 0.370–0.509; P < 0.001), hemoglobin (HB) (aOR, 95% CI 0.979, 0.971–0.987; P < 0.001) and platelets (PLT) (aOR, 95% CI 0.996, 0.994–0.999; P < 0.001) were independently associated with liver fibrosis in patients with schistosomiasis. ROC analysis indicated that the combination of HDL, LDL and HB levels [(HDL × 100)/(LDL × HB)] had a higher area under the ROC curve (AUC = 0.773), and thus may better predict liver fibrosis than the aspartate transaminase-to-platelet ratio index (AUC = 0.608) and fibrosis index based on four factors (AUC = 0.624).
Conclusions
To the best of our knowledge, this is the first study to report that HDL, LDL, HB and PLT levels are independently associated with liver fibrosis in patients with schistosomiasis. (HDL × 100)/(LDL × HB) outperformed the aspartate transaminase-to-platelet ratio index and fibrosis index based on four factors in terms of ROC, and thus could be a new predictive index for liver fibrosis. These findings may help clinicians to more easily and effectively diagnose liver fibrosis in patients with schistosomiasis.
Graphical abstract
Funder
National Natural Science Foundation of China
Key Research and Development Program of Hunan Province of China
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
Reference48 articles.
1. World Health Organization. Schistosomiasis. 2021. https://www.who.int/news-room/fact-sheets/detail/schistosomiasis. Accessed 2 July 2021.
2. McManus DP, Dunne DW, Sacko M, Utzinger J, Vennervald BJ, Zhou X-N. Schistosomiasis. Nat Rev Dis Prim. 2018;4:13.
3. Zhang L, Zhimin XU, Qian Y, Dang H, Shan LV, Jing XU, et al. Endemic status of schistosomiasis in People’s Republic of China in 2015. Chin J Schistosomiasis Control. 2016;28:611–7.
4. Zhou X-N, Wang L-Y, Chen M-G, Wu X-H, Jiang Q-W, Chen X-Y, et al. The public health significance and control of schistosomiasis in China—then and now. Acta Trop. 2005;96:97–105.
5. Zhang LJ, Xu ZM, Guo JY, Dai SM, Dang H, Lü S, et al. Endemic status of schistosomiasis in People’s Republic of China in 2018. (Zhongguo xue xi chong bing fang zhi za zhi). J Schistosomiasis Control. 2019;31:576–82.
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