Author:
Ayalew Samuel Belay,Daniel Tinbite,Samuel Hirbo,Endeshaw Amanuel Sisay,Bayu Habtu Tsehayu
Abstract
Abstract
Background
Post-operative sore throat is the common complaint and uncomfortable side effect in patients receiving general anesthesia with endotracheal intubation. Drugs with analgesic and anti-inflammatory properties, like steroids and local anesthetics, are the best options for postoperative sore throat prophylaxis. Therefore, this study aimed to compare the effects of intravenous lidocaine and dexamethasone in reducing postoperative sore throat following endotracheal extubation at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, from January 1 to March 30, 2023 G.C.
Methods
A prospective cohort study was carried out at Tikur Anbessa Specialized Hospital. Data from 50 patients in the lidocaine (1.5 mg/kg), 50 in the dexamethasone (8 mg), and 49 in the control groups were analyzed. The data were collected using observation based on structured questionnaires. A systematic random sampling technique was applied to select respondents. The data were entered into EpiData version 4.6.0.6 and transferred to STATA version 17 statistical software for analysis. A comparison of continuous data among the groups were performed using a one-way ANOVA test for parametric data. The Kruskal–Wallis rank test was used for non-parametric data. Associations between variables were tested using chi-squared test, Fisher’s exact test, and binary logistic regression. Bivariable and multivariable logistic regression was used to determine degree of association.
Results
The incidence of POST was 40%, 32%, and 57.1% in the lidocaine, dexamethasone, and control groups, respectively (P = .0356). Dexamethasone reduced the incidence of POST during the first 24 h (AOR: 0.374, 95% CI: 0.149–0.939). However, no difference was observed in the severity of POST at 3 h (p = 0.130), 6 h (p = 0.096), 12 h (p = 0.313), and 24 h (p = 0.525) of the post-extubation period among the three groups. IV lidocaine did not effectively reduce the incidence and severity of postoperative sore throat at different time intervals.
Conclusion and recommendation
Intravenous dexamethasone is more effective than intravenous lidocaine in reducing the incidence of postoperative sore throat among the groups. Based on these findings, intravenous dexamethasone is recommended to decrease the incidence of postoperative sore throat.
Publisher
Springer Science and Business Media LLC
Reference32 articles.
1. Liu Q, Wang Y, Zhuang R, Bao L, Zhu L, Zhou Y. Implementation of evidence in preventing postoperative sore throat of patients undergoing general anesthesia intubation using the i-PARIHS framework. Comput Intell Neurosci. 2022;10(9):1–9.
2. Cho C, Kim J, Yang H, Sung T, Kwon H, Kang P. The effect of combining lidocaine with dexamethasone for attenuating postoperative sore throat, cough, and hoarseness. Anesth Pain Med. 2016;11(7):42–8.
3. Gambrell C. Evidence-based best practice policy recommendation for postoperative sore throat. Univ South Mississippi Aquil Digit Community Dr Proj. 2019;127(1):1–44.
4. Subedi A, Tripathi M, Pokharel K, Khatiwada S. Effect of intravenous lidocaine, dexamethasone, and their combination on postoperative sore throat: a randomized controlled trial. Anesth Analg. 2019;129(1):220–5.
5. Tanaka Y, Nakayama T, Nishimori M, Tsujimura Y, Kawaguchi M, Sato Y. Lidocaine for preventing postoperative sore throat. Cochrane database Syst Rev. 2015;7:1–47.