Author:
Geng Chuan,Hu Baoji,Jiang Jihong,Zhang Yunhe,Tang Weiqing,Pan Mengzhi,Sun Leilei,Chen Peifen,Wang Hengyue
Abstract
Abstract
Background
Postoperative cognitive dysfunction (POCD) has been reported as a significant complication in elderly patients. Various methods have been proposed for reducing the incidence and severity of POCD. Intravenous lidocaine administration has been reported in the literature to reduce POCD, but the effect of lidocaine remains controversial.
Methods
We screened Medline, Embase, Cochrane Library, and China National Knowledge Infrastructure (up to April 2022) databases following a search strategy for intravenous lidocaine on POCD. We also screened related bibliographies on lidocaine for POCD. Ten articles comprising 1517 patients were selected and analyzed. We divided the postoperative follow-up period as follows: short term (<30 days), medium term (30–90 days), and long term (>90 days).
Outcomes
We found that lidocaine could attenuate the overall incidence of POCD, especially in the short term. There were no differences between lidocaine and placebo on the overall severity of POCD.
Conclusion
Lidocaine administered intravenously could attenuate the overall incidence of POCD and its severity in the short term.
Funder
NSFC
talent trainng program of Shanghai Pudong Hospital
Publisher
Springer Science and Business Media LLC
Subject
Anesthesiology and Pain Medicine
Reference49 articles.
1. Choi EJ, Choi YJ, Lee SW, Choi YM, Ri HS, Park JY, Park SJ, Son JM, Lee YS. Effect of anesthetic method on incidence of delirium after total hip replacement arthroplasty in South Korea: a population-based study using National Health Insurance claims data. Korean J Anesthesiol. 2020;73(1):36–43.
2. Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engstrom KG. Delirium after cardiac surgery: incidence and risk factors. Interact Cardiovasc Thorac Surg. 2013;17(5):790–6.
3. Boodhwani M, Rubens FD, Wozny D, Rodriguez R, Alsefaou A, Hendry PJ, Nathan HJ. Predictors of early neurocognitive deficits in low-risk patients undergoing on-pump coronary artery bypass surgery. Circulation. 2006;114(1 Suppl):I461–466.
4. Sugimura Y, Sipahi NF, Mehdiani A, Petrov G, Awe M, Minol JP, Boeken U, Korbmacher B, Lichtenberg A, Dalyanoglu H. Risk and consequences of postoperative delirium in cardiac surgery. Thorac Cardiovasc Surg. 2020;68(5):417–24.
5. Migirov A, Chahar P, Maheshwari K. Postoperative delirium and neurocognitive disorders. Curr Opin Crit Care. 2021;27(6):686–93.
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