Abstract
Abstract
Background
Breastfeeding an infant exposed to Human Immunodeficiency Virus (HIV) carries the risk of HIV acquisition whilst not breastfeeding poses a higher risk of death from malnutrition, diarrhea, and pneumonia. In Uganda, mothers living with HIV are encouraged to discontinue breastfeeding at 12 months but data are limited. We examined the frequency and factors associated with cessation of breastfeeding at 1 year among mothers living with HIV at Ndejje Health Center IV, a large peri-urban health facility in Uganda.
Methods
This retrospective cohort study involved all mothers living with HIV and enrolled in HIV care for ≥12 months between June 2014 and June 2018. We abstracted data from registers, held focus group discussions with mothers living with HIV and key informant interviews with healthcare providers. Cessation of breastfeeding was defined as the proportion of mothers living with HIV who had discontinued breastfeeding at 1 year. We summarized quantitative data descriptively, tested differences in outcome using Chi-square and t - tests, and established independently associated factors using modified Poisson regression analysis at 5% statistical significance level. We thematically analyzed qualitative data to enrich and triangulate the quantitative results.
Results
Of 235 participants, 150 (63.8%) had ceased breastfeeding at 1 year and this was independently associated with the infant being male (Adjusted Risk Ratio [aRR] 1.25, 95% confidence interval [CI] 1.04, 1.50), the mother being multiparous (aRR 1.26, 95% CI 1.04–1.53), and the initiation of breastfeeding being on the same-day as birth (aRR 0.06, 95% CI 0.01–0.41). The reasons for ceasing breastfeeding included male infants over breastfeed than females, maternal literacy and knowledge adequacy about breastfeeding, support and reminders from the partner, and boys can bite once they get teeth.
Conclusion
Suboptimal proportion of infants were ceased from breastfeeding at 1 year and this might increase the risk of mother to child transmission of HIV. Cessation of breastfeeding was more likely among male infants and multiparous mothers but less likely when breastfeeding was initiated on the same-day as birth. Interventions to enhance cessation of breastfeeding should target none multiparous mothers and those with female infants.
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology,Pediatrics, Perinatology and Child Health
Reference26 articles.
1. World Health Organization (WHO). Guideline: updates on HIV and infant feeding: duration of breastfeeding, and support from health services to improve feeding practices among mothers living with HIV; 2016.
2. UNAIDS. Country factsheets Uganda 2018: UNAIDS; 2018. [Cited 2020 March 10]. Available from: https://www.unaids.org/en/regionscountries/countries/uganda.
3. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, Vwalika C, et al. Prolonged breast feeding and mortality up to two years post-partum among HIV-positive women in Zambia. AIDS. 2005;19(15):1677–8.
4. Duber HC, Dansereau E, Masters SH, Achan J, Burstein R, DeCenso B, et al. Uptake of WHO recommendations for first-line antiretroviral therapy in Kenya, Uganda, and Zambia. PLoS One. 2015;10(3):e0120350.
5. Ladner J, Besson M-H, Rodrigues M, Saba J, Audureau E. Performance of HIV prevention of mother-to-child transmission programs in sub-Saharan Africa: longitudinal assessment of 64 Nevirapine-based programs implemented in 25 countries, 2000-2011. PLoS One. 2015;10(6):e0130103.