Author:
Patramool Sirilaksana,Surasombatpattana Pornapat,Luplertlop Natthanej,Sévéno Martial,Choumet Valérie,Thomas Frédéric,Missé Dorothée
Abstract
Abstract
Background
Proteomic analysis was performed to identify proteins regulated during infection by Dengue serotypes 1 and 3 in an Aedes albopictus cell line. The potential of these viruses to cause severe disease at primary infection is of interest although few studies have been performed with these two Dengue serotypes.
Results
The most relevant observation of our study is the significant overexpression of proteins involved in the cellular stress response and the glycolysis pathway after 48 hours of infection. Viral infection activates the translation of some host genes, which may result in stress due to responses involving unfolded proteins.
Conclusions
Therefore, the oxidation reduction and glycolytic mechanisms could participate in the antiviral response against Dengue virus. The results of our study should help to improve our knowledge of the virus-mosquito interaction at a cellular level with the aim of designing efficient strategies for the control of Dengue virus.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Parasitology
Cited by
34 articles.
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