Abstract
AbstractControl of Infectious diseases such as; bacteria and viruses, has become a globally critical issue, since the appearance of COVID-19 virus in 2020. In addition to the microbial resistance of the currently available therapeutic drugs as well as, its prolonged side effects make its use is of health care concern. Green nanotechnology approach is a promising solution for controlling such infectious diseases and many biomedical purposes. In the present study, green synthesis approach based on microwave-assisted hydrothermal method is an innovative and environmentally friendly method for preparation of bioactive CeO2 and ZnO nanorod structured materials using Olea europaea (O. e.) leaf plant extract as a natural medicinal capping agent for controlling the shape and size of nano-products. The optical and structural analyses of the obtained nanorod-structures are characterized using; TEM, FTIR, XRD, SBET analyses and particle size analyzer. The green-synthesized ZnO and CeO2 nanorods display an average crystallite size of approximately 15 and 5 nm, respectively. The antimicrobial activity of ZnO and CeO2 nanorods compared with the traditional hydrothermal methods, was examined on six clinical pathogens including; (E. coli Serratia sp., S. aureus, Bacillus subtilis, Streptococcus mutant, and MRSA). The results indicated superior antimicrobial and anti-tumor activities towards hepatocellular carcinoma cell lines (IC50 = 117.24 and 103.50 μg mL−1 for ZnO and CeO2 and LD50 > 3000 mg kg−1). This demonstrates that the green microwave process is a promising approach for the synthesis of effective ZnO and CeO2 nanomaterials applied for many biomedical applications.
Funder
science and technology develpment fund
University of Sadat City
Publisher
Springer Science and Business Media LLC
Subject
Applied Microbiology and Biotechnology,Biophysics
Reference36 articles.
1. Abdelmordy O (2017) Preparation and characterization of composite semiconductor nanomaterials and its environmental applications for solar photocatalytic degradation of some industrial wastewater pollutants. MSc thesis. Environmental studies and research institute University of Sadat City Menoufia Egypt: 30–31.
2. Abdo AM, Fouda A, Eid AM, Fahmy NM, Elsayed AM, Khalil AAM, Alzahrani OM, Ahmed AF, Soliman AM (2021) Green synthesis of Zinc Oxide nanoparticles (ZnO-NPs) by Pseudomonas aeruginosa and their activity against pathogenic microbes and common house mosquito Culexpipiens. J Mater 14:6983. https://doi.org/10.3390/ma14226983
3. Alahmdi MI, Syed K, Vanaraj S, Panneerselvam C, Mahmoud MAA, Mukhtar S, Alsharif MA, Zidan NS, Abo-Dya NE, Aldosari OF (2022) Invitro anticancer and antibacterial activity of green synthesized ZnO NPs using Clitorea ternatea flower extract: inhibits MCF-7 cell proliferation via intrinsic apoptotic pathway. J Res Sq. 28(1):227–244. https://doi.org/10.21203/rs.3.rs-1269775/v1
4. Aljabali AA, Obeid MA, Bakshi HA, Alshaer W, Ennab RM, Al-Trad B, Al Khateeb W, Al-Batayneh KM, Al-Kadash A, Alsotari S, Nsairat H, Tambuwala MM (2022) Synthesis, characterization and assessment of anti-cancer potential of ZnO nanoparticles in an in vitro model of breast cancer. J Molecules 27:18–27. https://doi.org/10.3390/molecules27061827
5. Alrubaie EAA, kadhim RE, (2019) Synthesis of ZnO nanoparticles from olive plant extract. J Plant Arch 19(2):339–344
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献