The route of SARS-CoV-2 to brain infection: have we been barking up the wrong tree?-Reference-Cited by-同舟云学术

The route of SARS-CoV-2 to brain infection: have we been barking up the wrong tree?

Published:2022-03-15 Issue:1 Volume:17 Page:
ISSN:1750-1326
Container-title:Molecular Neurodegeneration
language:en
Short-container-title:Mol Neurodegeneration

Author:

Butowt Rafal^ORCID,von Bartheld Christopher S.

Abstract

AbstractThis letter draws attention to recent work supporting the notion that the SARS-CoV-2 virus may use the nervus terminalis rather than the olfactory nerve as a shortcut route from the nasal cavity to infect the brain.

Funder

Foundation for the National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Molecular Biology

Link

https://link.springer.com/content/pdf/10.1186/s13024-022-00529-9.pdf

Reference15 articles.

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3. Butowt R, Meunier N, Bryche B, von Bartheld CS. The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models. Acta Neuropathol. 2021;141(6):809–22. https://doi.org/10.1007/s00401-021-02314-2.

4. Jiao L, Yang Y, Yu W, Zhao Y, Long H, Gao J, et al. The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys. Signal Transduct Target Ther. 2021;6(1):169. https://doi.org/10.1038/s41392-021-00591-7.

5. van Riel D, Verdijk R, Kuiken T. The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. J Pathol. 2015;235(2):277–87. https://doi.org/10.1002/path.4461.

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