Abstract
Abstract
Background
Psoriatic arthritis is a chronic inflammatory condition associated with psoriasis, which affects joints. The coexistence of vasculitis, an inflammation of blood vessels, with psoriatic arthritis is rare, highlighting a complex interplay between autoimmune diseases that affect both joints and vascular structures.
Case presentation
We report on a 56-year-old male with a long-standing history of psoriasis and psoriatic arthritis, who presented with new-onset skin lesions and neurological symptoms. Clinical evaluations confirmed the presence of leukocytoclastic vasculitis and asymmetric sensory motor axonal neuropathy. The absence of positive results from various standard tests led to a challenging diagnostic process, ultimately pointing towards vasculitis associated with psoriatic arthritis. The patient was treated with corticosteroids and immunosuppressive therapy, leading to partial symptom improvement.
Conclusions
This case underlines the complex and often overlapping nature of autoimmune conditions, particularly the occurrence of vasculitis in patients with psoriatic arthritis, which is rare. It stresses the importance of considering vasculitis in patients with psoriatic arthritis who present with unexplained skin lesions and neurological symptoms. This case adds to the spectrum of psoriatic disease manifestations and suggests a need for further research to explore the underlying mechanisms and improve management strategies.
Publisher
Springer Science and Business Media LLC
Reference14 articles.
1. Menter A (2016) Psoriasis and psoriatic arthritis overview. Am J Manag Care 22(8 Suppl):s216-24
2. Azuaga AB, Ramírez J, Cañete JD (2023) Psoriatic arthritis: pathogenesis and targeted therapies. Int J Mol Sci 24(5):4901
3. Schön MP, Wilsmann-Theis D (2023) Current developments and perspectives in psoriasis. J Dtsch Dermatol Ges 21(4):363–72
4. Urrea-Pineda LY, Gómez-Jiménez S, Jaramillo-Arroyave D, Muñoz-Vahos CH, Vanegas-García AL, Vasquéz G et al (2020) Cryoglobulinemic vasculitis and psoriatic arthritis: case report of an unusual association. Reumatol Clin (Engl Ed) 16(3):242–4
5. Palazzi C, D’Amico E, Pennese E, Petricca A, Olivieri I (2006) Purpura and serum mixed cryoglobulinemia in psoriatic arthritis. Rheumatol Int. 27(2):187–9