Abstract
Abstract
Background
Infantile hemangiomas (IHs) are common vascular tumors. Although it involutes spontaneously, outcomes are unpredictable. Intralesional therapy is one of its treatment modality. We present our experience with combined intralesional therapy for IHs over a 5-year duration. A total of 427 patients were treated and followed at Al-Azhar University Hospitals during the study period of 5 years. All patients were treated by intralesional therapy in the form of combined injection of triamcinolone and bleomycin. All patients were followed for the response. Response to the treatment was graded as marked, partial, and poor improvement.
Results
IHs were noticed within the first month of life in 90.2% of patients. The commonest site of involvement was head and neck in 90% of patients. The commonest clinical presentation was swelling with discoloration. Mean age was 7.43 ± 6.04 months and mean IHs size was 15.54 ± 11.13 cm2. The response to the treatment was highest for patients below 1 year of age. The reported complications were ulceration, scarring, and subcutaneous atrophy in some cases.
Conclusion
Combined intralesional therapy in IHs showed good efficacy in most patients. It is a reliable and safe treatment modality with clear curative effects and minimal complications. If IHs treatment is indicated, combined intralesional therapy should be considered as an alternative effective treatment modality.
Publisher
Springer Science and Business Media LLC
Subject
Pediatrics, Perinatology and Child Health,Surgery
Reference36 articles.
1. Ahuja T, Jaggi N, Kalra A, Bansal K, Sharma SP. Hemangioma: review of literature. The journal of contemporary dental practice. 2013;14(5):1000–7.
2. Antonescu C. Malignant vascular tumors--an update, Modern pathology: an official journal of the United States and Canadian Academy of Pathology. Inc. 2014;27(Suppl 1):S30–8.
3. Arkan Hadi A, Ashraf Hashim A, Fadel Abbas A. Intralesional triamcinolone injection in the management of cutaneous hemangiomas in children. Medical Journal of Babylon. 2012;9(1):182–7.
4. Berlien HP. Classification of infantile hemangiomas and other congenital vascular tumors. In: Mattassi R, Loose DA, Vaghi M, editors. hemangiomas and vascular malformations: an atlas of diagnosis and treatment. Milano: Springer Milan; 2009. p. 23–34.
5. Boscolo E, Bischoff J. Vasculogenesis in infantile hemangioma. Angiogenesis. 2009;12(2):197–207.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献