Author:
Xun Jingna,Qi Tangkai,Zou Lei,Tang Qi,Shen Yinzhong,Yang Junyang,Xie Luman,Ji Yongjia,Zhang Renfang,Liu Li,Wang Jiangrong,Steinhart Corky,Wang Zhenyan,Tang Yang,Song Wei,Sun Jianjun,Cheng Juan,Le Xiaoqin,Wu Huanmei,He Xiaoqing,Chen Rong,Chen Jun,Lu Hongzhou
Abstract
Abstract
Background
Tuberculosis (Tb) is the most frequent opportunistic infection among people living with HIV infection. The impact of Tb co-infection in the establishment and maintenance of the HIV reservoir is unclear.
Method
We enrolled 13 HIV-infected patients with microbiologically confirmed Tb and 10 matched mono-HIV infected controls. Total HIV DNA in peripheral blood mononuclear cells (PBMCs), plasma interleukin-7 (IL-7) concentrations and the activities of indoleamine 2,3-dioxygenase (IDO) were measured for all the participants prior to therapy and after antiretroviral therapy (ART).
Results
After a duration of 16 (12, 22) months’ ART, patients co-infected with Tb who were cured of Tb maintained higher levels of HIV DNA compared with mono-HIV infected patients [2.89 (2.65- 3.05) log10 copies/106 cells vs. 2.30 (2.11–2.84) log10 copies/106 cells, P = 0.008]. The levels of on-ART HIV DNA were positively correlated with the baseline viral load (r = 0.64, P = 0.02) in Tb co-infected group. However, neither plasma IL-7 concentration nor plasma IDO activity was correlated with the level of on-ART HIV DNA.
Conclusions
Tb co-infection was associated with the increased surrogate marker of the HIV reservoir, while its mechanism warrants further examination.
Funder
the National Science and Technology Major Project of China
the National Natural Science Foundation of China
the Medical Science Support Program of the Shanghai Science and Technology Committee
the Medical Guidance Support Project of Shanghai Science and Technology Commission
the Shanghai Rising stars of Medical Talent Youth Development Program
the project of Shanghai Municipal Key Clinical Specialty
the Shanghai Municipal Commission of Health and Family Planning
the academy level project of Shanghai Public Health Clinical Center
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Virology,Molecular Medicine
Cited by
10 articles.
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