Author:
Jonas Kamil,Kurzyna Marcin,Mroczek Ewa,Chrzanowski Łukasz,Mularek-Kubzdela Tatiana,Skoczylas Ilona,Błaszczak Piotr,Grześk Grzegorz,Mizia-Stec Katarzyna,Kuśmierczyk Beata,Kamiński Karol,Lewicka Ewa,Peregud-Pogorzelska Małgorzata,Tomaszewski Michał,Jacheć Wojciech,Gąsior Zbigniew,Pawlak Agnieszka,Ryczek Robert,Pruszczyk Piotr,Doboszyńska Anna,Widejko-Pietkiewicz Katarzyna,Zabłocka Wiesława,Waligóra Marcin,Kopeć Grzegorz
Abstract
Abstract
Background
Recent studies revealed that alterations in glucose and lipid metabolism in idiopathic pulmonary arterial hypertension (IPAH) are associated with disease severity and poor survival. However, data regarding the impact of diabetes mellitus (DM) on the prognosis of patients with IPAH remain scarce. The aim of our study was to determine that impact using data from a national multicentre prospective pulmonary hypertension registry.
Methods
We analysed data of adult patients with IPAH from the Database of Pulmonary Hypertension in the Polish population (BNP‑PL) between March 1, 2018 and August 31, 2020. Upon admission, clinical, echocardiographic, and haemodynamic data were collected at 21 Polish IPAH reference centres. The all-cause mortality was assessed during a 30-month follow-up period. To adjust for differences in age, body mass index (BMI), and comorbidities between patients with and without DM, a 2-group propensity score matching was performed using a 1:1 pairing algorithm.
Results
A total of 532 patients with IPAH were included in the study and 25.6% were diagnosed with DM. Further matched analysis was performed in 136 patients with DM and 136 without DM. DM was associated with older age, higher BMI, more advanced exertional dyspnea, increased levels of N-terminal pro–brain natriuretic peptide, larger right atrial area, increased mean right atrial pressure, mean pulmonary artery pressure, pulmonary vascular resistance, and all-cause mortality compared with no DM.
Conclusions
Patients with IPAH and DM present with more advanced pulmonary vascular disease and worse survival than counterparts without DM independently of age, BMI, and cardiovascular comorbidities.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism
Cited by
2 articles.
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