Author:
Zhou Yiling,Liu Li,Huang Hongmei,Li Nan,He Jidong,Yao Heling,Tang Xiaochi,Chen Xiangyang,Zhang Shengzhao,Shi Qingyang,Qu Furong,Wang Si,Wang Miye,Shu Chi,Zeng Yuping,Tian Haoming,Zhu Ye,Su Baihai,Li Sheyu,
Abstract
Abstract
Objective
To evaluate the impact of stress hyperglycemia on the in-hospital prognosis in non-surgical patients with heart failure and type 2 diabetes.
Research design and methods
We identified non-surgical hospitalized patients with heart failure and type 2 diabetes from a large electronic medical record-based database of diabetes in China (WECODe) from 2011 to 2019. We estimated stress hyperglycemia using the stress hyperglycemia ratio (SHR) and its equation, say admission blood glucose/[(28.7 × HbA1c)− 46.7]. The primary outcomes included the composite cardiac events (combination of death during hospitalization, requiring cardiopulmonary resuscitation, cardiogenic shock, and the new episode of acute heart failure during hospitalization), major acute kidney injury (AKI stage 2 or 3), and major systemic infection.
Results
Of 2875 eligible Chinese adults, SHR showed U-shaped associations with composite cardiac events, major AKI, and major systemic infection. People with SHR in the third tertile (vs those with SHR in the second tertile) presented higher risks of composite cardiac events ([odds ratio, 95% confidence interval] 1.89, 1.26 to 2.87) and major AKI (1.86, 1.01 to 3.54). In patients with impaired kidney function at baseline, both SHR in the first and third tertiles anticipated higher risks of major AKI and major systemic infection.
Conclusions
Both high and low SHR indicates poor prognosis during hospitalization in non-surgical patients with heart failure and type 2 diabetes.
Funder
the Sichuan Science and Technology Program
1·3·5 project for disciplines of excellence–Clinical Research Incubation Project, West China Hospital, Sichuan University
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism
Cited by
21 articles.
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