Author:
Faheem Sanam,Maqsood Shahida,Hasan Arshad,Imtiaz Fouzia,Shaikh Faheem,Farooqui Waqas Ahmed
Abstract
Abstract
Background
Human beta defensin-3 (HβD-3) is an antimicrobial peptide present in saliva that protects tooth surfaces from microbial attack. These peptides are part of innate immunity so levels may be affected by different systemic diseases like anemia. Therefore, anemia may predispose an affected child to an increased risk of dental caries. The objectives of this study were to determine the association of early childhood caries (ECC) with HβD-3 levels and observe the association of HβD-3 levels with childhood anemia.
Methods
A total of 80 children admitted in a pediatric medical ward, age 48–71 months, of either sex were included in the study. The included children were categorized as cases (children with ECC n = 40) and controls (children without ECC n = 40). Children were further segregated into the anemic and non-anemic sub-groups based on the hospital record of hemoglobin level. The salivary concentration of HβD-3 was measured by Enzyme-Linked Immuno-sorbent assay (ELISA). IBM SPSS version 20 software was used for statistical analysis. Two sample t-test and one-way ANOVA were used to compare mean values while spearman was used for correlations at p < 0.05.
Results
The mean Salivary HβD-3 level in cases (8.87 ± 4.30) was significantly higher (p = 0.042) as compared to controls (7.23 ± 2.57). Salivary HβD-3 level in patients with caries and without anemia was highest (10.80 ± 4.50) whereas salivary HβD-3 level in the presence of caries and anemia was lowest (6.94 ± 3.13) amongst all groups. This difference was statistically significant (p = 0.001). Salivary HβD-3 level was found to be moderately correlated with cases (p = 0.002). An inverse correlation was found between salivary HβD-3 level and anemia (r = -0.479, p = 0.002).
Conclusion
Anemia may affect the innate immunity of children, and may result in a decreased level of salivary HβD3, thus increasing vulnerability to decay.
Publisher
Springer Science and Business Media LLC
Reference38 articles.
1. Kirthiga M, Murugan M, Saikia A, Kirubakaran R. Risk factors for early childhood caries: a systematic review and meta-analysis of case control and cohort studies. Pediatr Dent. 2019;41(2):95–112.
2. Chen KJ, Gao SS, Duangthip D, Lo EC, Chu CH. Prevalence of early childhood caries among 5-year-old children: a systematic review. J Investig Clin Dent. 2019;10(1):12376.
3. Begzati A, Berisha M, Mrasori S, Xhemajli-Latifi B, Prokshi R, Haliti F, Maxhuni V, Hysenaj-Hoxha V, Halimi V. Early childhood caries (ECC)—etiology, clinical consequences and prevention. Emerg Trends Oral Health Sci Dent. 2015:31.
4. Navarra CO, Robino A, Pirastu N, Bevilacqua L, Gasparini P, Di Lenarda R, Crovella S. Caries and innate immunity: DEFB1 gene polymorphisms and caries susceptibility in genetic isolates from north-eastern Italy. Caries Res. 2016;50(6):589–94.
5. Moslemi M, Sattari M, Kooshki F, Fotuhi F, Modarresi N, Sadrabad ZK, Shadkar MS. Relationship of salivary lactoferrin and lysozyme concentrations with early childhood caries. J Dent Res Dent Clin Dent Prospects. 2015;9(2):109.
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