Author:
Wang Yueyue,Fan Qin,Xu Yanglong,Zeng Fengjiao,Liu Xia,Zhao Dan,Zhang Lei,Bai Guohui
Abstract
AbstractHerein, we evaluated the potential therapeutic effects of water extracts from Eucommia on periodontitis in experimental rats. We ligated the maxillary second molars of Sprague–Dawley(SD) rats with 4.0 silk threads and locally smeared Porphyromonas gingivalis(P. gingivalis) to induce gingivitis and periodontitis.After the model was successfully established, we exposed the rats to Eucommia water extracts through topical smearing and intragastric administration and evaluated the therapeutic effect of the extracts on gingivitis (for a 2 week treatment period) and periodontitis (over 4 weeks). We analyzed histopathological sections of the periodontal tissue and quantified the alveolar bone resorption levels, molecules related to periodontal oxidative stress, and periodontal inflammatory factors to assess the feasibility of Eucommia in treating gingivitis and periodontitis. We found that damage to the periodontal tissue was reduced after treatment with extracts,indicating that Eucommia has a positive effect in treating gingivitis and periodontitis in experimental rats. These findings are expected to provide the foothold for future research on secondary metabolites derived from Eucommia and guide the development of novel approaches for preventing and treating periodontal disease.
Funder
NSFC "study on the mechanism of Eucommia ulmoides ubiquitin ligase eupub21 regulating eufps1"
Construction Projects of Medical Biomaterial Research & Development Talent Base in Guizhou Province and Zunyi City
Zunyi science and technology support plan project: Zunyi Kehe Hz Zi
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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