Author:
Zhang Zhixia,Yu Wenyi,Li Guangyao,He Yukun,Shi Zhiming,Wu Jing,Ma Xinqian,Zhu Yu,Zhao Lili,Liu Siqin,Wei Yue,Xue Jianbo,Guo Shuming,Gao Zhancheng
Abstract
AbstractThe environment of healthcare institutes (HCIs) potentially affects the internal microecology of medical workers, which is reflected not only in the well-studied gut microbiome but also in the more susceptible oral microbiome. We conducted a prospective cross-sectional cohort study in four hospital departments in Central China. Oropharyngeal swabs from 65 healthcare workers were collected and analyzed using 16S rRNA gene amplicon sequencing. The oral microbiome of healthcare workers exhibited prominent deviations in diversity, microbial structure, and predicted function. The coronary care unit (CCU) samples exhibited robust features and stability, with significantly higher abundances of genera such as Haemophilus, Fusobacterium, and Streptococcus, and a lower abundance of Prevotella. Functional prediction analysis showed that vitamin, nucleotide, and amino acid metabolisms were significantly different among the four departments. The CCU group was at a potential risk of developing periodontal disease owing to the increased abundance of F. nucleatum. Additionally, oral microbial diversification of healthcare workers was related to seniority. We described the oral microbiome profile of healthcare workers in different clinical scenarios and demonstrated that community diversity, structure, and potential functions differed markedly among departments. Intense modulation of the oral microbiome of healthcare workers occurs because of their original departments, especially in the CCU.
Funder
Key Medical Research Project of Shanxi Province
Key Research and Development Plan of Linfen Science and technology
Clinical Medical Research Center of Linfen Central Hospital
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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