Author:
Ren Zhen-Hu,Liu Keyue,Chen Yiming,Yang Zhi-Min,Wu Kun,Wu Han-Jiang
Abstract
Abstract
Introduction
A prospective observational study was modified to assess the efficacy of surgery alone for the treatment of locally advanced oral squamous cell carcinoma. (LA-OSCC)
Materials and methods
This prospective, single-institution, single-arm study involved 174 patients who underwent major surgery for LA-OSCC. Participating patients did not receive postoperative radiation. After initial curative treatment, patients were routinely monitored via clinical examination and imaging. The follow-up period was 3–70 months. Tumour recurrence and death were considered as the Clinical End Point in Research.
Results
The 5-year overall survival (OS), disease-free survival (DFS), and locoregional control rates for 174 patients were 66.7% (95% confidence interval [CI], 59.8 to 73.6), 66.1% (95% CI, 59.2 to 73.0), and 82.4% (95% CI, 76.5 to 88.3), respectively.
Conclusion
A study of patients with LA-OSCC treated with surgery alone may have the optimal therapeutic impact for LA-OSCC, as evidenced by solid data for our next RCT trial. This conclusion still needs to be validated in higher-level RCTs.
Funder
Hainan Provincial Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC