Author:
Mas Aran,Noble Peter-John M,Cripps Peter J,Batchelor Daniel J,Graham Peter,German Alexander J
Abstract
Abstract
Background
Enzyme treatment is the mainstay for management of exocrine pancreatic insufficiency (EPI) in dogs. ‘Enteric-coated’ preparations have been developed to protect the enzyme from degradation in the stomach, but their efficacy has not been critically evaluated. The hypothesis of the current study was that enteric coating would have no effect on the efficacy of pancreatic enzyme treatment for dogs with EPI.
Thirty-eight client-owned dogs with naturally occurring EPI were included in this multicentre, blinded, randomised controlled trial. Dogs received either an enteric-coated enzyme preparation (test treatment) or an identical preparation without the enteric coating (control treatment) over a period of 56 days.
Results
There were no significant differences in either signalment or cobalamin status (where cobalamin deficient or not) between the dogs on the test and control treatments. Body weight and body condition score increased in both groups during the trial (P<0.001) but the magnitude of increase was greater for the test treatment compared with the control treatment (P<0.001). By day 56, mean body weight increase was 17% (95% confidence interval 11-23%) in the test treatment group and 9% (95% confidence interval 4-15%) in the control treatment group. The dose of enzyme required increased over time (P<0.001) but there was no significant difference between treatments at any time point (P=0.225). Clinical disease severity score decreased over time for both groups (P=0.011) and no difference was noted between groups (P=0.869). No significant adverse effects were reported, for either treatment, for the duration of the trial.
Conclusions
Enteric coating a pancreatic enzyme treatment improves response in canine EPI.
Publisher
Springer Science and Business Media LLC
Subject
General Veterinary,General Medicine
Reference16 articles.
1. Westermarck E, Wiberg M, Steiner J, Williams DA: Exocrine pancreatic insufficiency in dogs and cats. In Textbook of veterinary internal medicine, Volume 2. 6th edition. Edited by Ettinger SJ, Feldman EC. St Louis: Elsevier Saunders; 2005:1492–1495.
2. Hall EJ, Bond PM, McLean C, Batt RM, McLean L: A survey of the diagnosis and treatment of canine exocrine pancreatic insufficiency. J Small Animal Pract. 1991, 32: 613-619. 10.1111/j.1748-5827.1991.tb00903.x.
3. Batchelor DJ, Noble PJM, Taylor RH, Cripps PJ, German AJ: Prognostic factors in canine exocrine pancreatic insufficiency: Prolonged survival is likely if clinical remission is achieved. J Vet Intern Med. 2007, 21: 54-60. 10.1111/j.1939-1676.2007.tb02928.x.
4. International Conference on Harmonisation: Good Clinical Practice. [http://www.ich.org/products/guidelines/efficacy/article/efficacy-guidelines.html]
5. Laflamme D: Development and validation of a body condition score system for dogs. Canine Pract. 1997, 22: 10-15.
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献