Author:
Van den Bossche Lindsay,van Steenbeek Frank G,Favier Robert P,Kummeling Anne,Leegwater Peter AJ,Rothuizen Jan
Abstract
Abstract
Background
An inherited basis for congenital extrahepatic portosystemic shunts (EHPSS) has been demonstrated in several small dog breeds. If in general both portocaval and porto-azygous shunts occur in breeds predisposed to portosystemic shunts then this could indicate a common genetic background. This study was performed to determine the distribution of extrahepatic portocaval and porto-azygous shunts in purebred dog populations.
Results
Data of 135 client owned dogs diagnosed with EHPSS at the Faculty of Veterinary Medicine of Utrecht University from 2001 – 2010 were retrospectively analyzed. The correlation between shunt localization, sex, age, dog size and breed were studied. The study group consisted of 54 males and 81 females from 24 breeds. Twenty-five percent of dogs had porto-azygous shunts and 75% had portocaval shunts. Of the dogs with porto-azygous shunts only 27% was male (P = 0.006). No significant sex difference was detected in dogs with a portocaval shunt. Both phenotypes were present in almost all breeds represented with more than six cases. Small dogs are mostly diagnosed with portocaval shunts (79%) whereas both types are detected. The age at diagnosis in dogs with porto-azygous shunts was significantly higher than that of dogs with portocaval shunts (P < 0.001).
Conclusion
The remarkable similarity of phenotypic variation in many dog breeds may indicate common underlying genes responsible for EHPSS across breeds. The subtype of EHPSS could be determined by a minor genetic component or modulating factors during embryonic development.
Publisher
Springer Science and Business Media LLC
Subject
General Veterinary,General Medicine
Reference19 articles.
1. Vulgamott JC: Portosystemic shunts. Vet Clin North Am Small Anim Pract. 1985, 15 (1): 229-242.
2. van Steenbeek FG, van den Bossche L, Leegwater PA, Rothuizen J: Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein. Mamm Genome. 2011, 23 (1–2): 76-84.
3. van Steenbeek FG, Leegwater PA, van Sluijs FJ, Heuven HC, Rothuizen J: Evidence of inheritance of intrahepatic portosystemic shunts in Irish Wolfhounds. J Vet Intern Med. 2009, 23 (4): 950-952. 10.1111/j.1939-1676.2009.0319.x.
4. Payne JT, Martin RA, Constantinescu GM: The anatomy and embryology of portosystemic shunts in dogs and cats. Semin Vet Med Surg (Small Anim). 1990, 5 (2): 76-82.
5. Martin RA: Congenital portosystemic shunts in the dog and cat. Vet Clin North Am Small Anim Pract. 1993, 23 (3): 609-623.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献