Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction-Reference-Cited by-同舟云学术

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Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

Published:2015-12 Issue:1 Volume:3 Page:
ISSN:2197-425X
Container-title:Intensive Care Medicine Experimental
language:en
Short-container-title:ICMx

Author:

Iba Toshiaki,Hashiguchi Naoyuki,Nagaoka Isao,Tabe Yoko,Kadota Katsuhiko,Sato Koichi

Funder

Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Link

http://link.springer.com/content/pdf/10.1186/s40635-015-0072-z.pdf

Reference31 articles.

1. Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F, Wang SS, Brohi K, Kipar A, Yu W, Wang G, Toh CH (2013) Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med 187:160–169

2. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F, Esmon CT (2009) Extracellular histones are major mediators of death in sepsis. Nat Med 15:1318–1321

3. Ekaney ML, Otto GP, Sossdorf M, Sponholz C, Boehringer M, Loesche W, Rittirsch D, Wilharm A, Kurzai O, Bauer M, Claus RA (2014) Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation. Crit Care 18:543

4. Levi M, Levy M, Williams MD, Douglas I, Artigas A, Antonelli M et al (2007) Xigris and Prophylactic HepaRin Evaluation in Severe Sepsis (XPRESS) Study Group. Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med 176:483–490

5. Jaimes F, De La Rosa G, Morales C, Fortich F, Arango C, Aguirre D et al (2009) Unfractioned heparin for treatment of sepsis: a randomized clinical trial (the HETRASE Study). Crit Care Med 37:1185–1196

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