Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asthmatic subjects
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Published:2023-07-10
Issue:1
Volume:20
Page:
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ISSN:1743-8977
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Container-title:Particle and Fibre Toxicology
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language:en
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Short-container-title:Part Fibre Toxicol
Author:
Laursen Karin Rosenkilde,Christensen Nichlas Vous,Mulder Frans AA,Schullehner Jörg,Hoffmann Hans Jürgen,Jensen Annie,Møller Peter,Loft Steffen,Olin Anna-Carin,Rasmussen Berit B.,Rosati Bernadette,Strandberg Bo,Glasius Marianne,Bilde Merete,Sigsgaard Torben,
Abstract
Abstract
Background
There is insufficient knowledge about the systemic health effects of exposure to fine (PM2.5) and ultrafine particles emitted from typical indoor sources, including cooking and candlelight burning. We examined whether short-term exposure to emissions from cooking and burning candles cause inflammatory changes in young individuals with mild asthma. Thirty-six non-smoking asthmatics participated in a randomized controlled double-blind crossover study attending three exposure sessions (mean PM2.5 µg/m3; polycyclic aromatic hydrocarbons ng/m3): (a) air mixed with emissions from cooking (96.1; 1.1), (b) air mixed with emissions from candles (89.8; 10), and (c) clean filtered air (5.8; 1.0). Emissions were generated in an adjacent chamber and let into a full-scale exposure chamber where participants were exposed for five hours. Several biomarkers were assessed in relation to airway and systemic inflammatory changes; the primary outcomes of interest were surfactant Protein-A (SP-A) and albumin in droplets in exhaled air – novel biomarkers for changes in the surfactant composition of small airways. Secondary outcomes included cytokines in nasal lavage, cytokines, C-reactive protein (CRP), epithelial progenitor cells (EPCs), genotoxicity, gene expression related to DNA-repair, oxidative stress, and inflammation, as well as metabolites in blood. Samples were collected before exposure start, right after exposure and the next morning.
Results
SP-A in droplets in exhaled air showed stable concentrations following candle exposure, while concentrations decreased following cooking and clean air exposure. Albumin in droplets in exhaled air increased following exposure to cooking and candles compared to clean air exposure, although not significant. Oxidatively damaged DNA and concentrations of some lipids and lipoproteins in the blood increased significantly following exposure to cooking. We found no or weak associations between cooking and candle exposure and systemic inflammation biomarkers including cytokines, CRP, and EPCs.
Conclusions
Cooking and candle emissions induced effects on some of the examined health-related biomarkers, while no effect was observed in others; Oxidatively damaged DNA and concentrations of lipids and lipoproteins were increased in blood after exposure to cooking, while both cooking and candle emissions slightly affected the small airways including the primary outcomes SP-A and albumin. We found only weak associations between the exposures and systemic inflammatory biomarkers. Together, the results show the existence of mild inflammation following cooking and candle exposure.
Funder
Realdania Forskning
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Reference99 articles.
1. Farrow A, Taylor H, Golding J. Time spent in the home by different family members. Environ Technol (United Kingdom). 1997;18(6):605–13. 2. Klepeis NE, Nelson WC, Ott WR, Robinson JP, Tsang AM, Switzer P, et al. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Anal Environ Epidemiol. 2001;11(3):231–52. 3. Morawska L, Ayoko GA, Bae GN, Buonanno G, Chao CYH, Clifford S, et al. Airborne particles in indoor environment of homes, schools, offices and aged care facilities: the main routes of exposure. Environ Int. 2017;108(August):75–83. 4. Patel S, Sankhyan S, Boedicker EK, Decarlo PF, Farmer DK, Goldstein AH, et al. Indoor particulate matter during HOMEChem: concentrations, size distributions, and exposures. Environ Sci Technol. 2020;54(12):7107–16. 5. Bekö G, Weschler CJ, Wierzbicka A, Karottki DG, Toftum J, Loft S, et al. Ultrafine particles: exposure and source apportionment in 56 danish homes. Environ Sci Technol. 2013;47(18):10240–8.
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