Abstract
Abstract
Background
Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and packaging.
Objective
The present review aimed at providing a comprehensive overview of current knowledge regarding the effects of nano- and microplastics on intestinal homeostasis.
Methods
We conducted a literature search focused on the in vivo effects of nano- and microplastics on gut epithelium and microbiota, as well as on immune response.
Results
Numerous animal studies have shown that exposure to nano- and microplastics leads to impairments in oxidative and inflammatory intestinal balance, and disruption of the gut’s epithelial permeability. Other notable effects of nano- and microplastic exposure include dysbiosis (changes in the gut microbiota) and immune cell toxicity. Moreover, microplastics contain additives, adsorb contaminants, and may promote the growth of bacterial pathogens on their surfaces: they are potential carriers of intestinal toxicants and pathogens that can potentially lead to further adverse effects.
Conclusion
Despite the scarcity of reports directly relevant to human, this review brings together a growing body of evidence showing that nano- and microplastic exposure disturbs the gut microbiota and critical intestinal functions. Such effects may promote the development of chronic immune disorders. Further investigation of this threat to human health is warranted.
Publisher
Springer Science and Business Media LLC
Subject
Health, Toxicology and Mutagenesis,Toxicology,General Medicine
Reference139 articles.
1. Wu P, Huang J, Zheng Y, Yang Y, Zhang Y, He F, et al. Environmental occurrences, fate, and impacts of microplastics. Ecotoxicol Environ Saf. 2019;184:109612.
2. Publications :: PlasticsEurope [Internet]. [cited 2020 Sep 7]. Available from: https://www.plasticseurope.org/fr/resources/publications/1804-plastics-facts-2019.
3. Alimba CG, Faggio C. Microplastics in the marine environment: current trends in environmental pollution and mechanisms of toxicological profile. Environ Toxicol Pharmacol. 2019;68:61–74.
4. Lambert S, Wagner M. Microplastics are contaminants of emerging concern in freshwater environments: an overview. Freshw Microplastics. Cham: Springer; 2018. p. 1–23.
5. Peeken I, Primpke S, Beyer B, Gütermann J, Katlein C, Krumpen T, et al. Arctic Sea ice is an important temporal sink and means of transport for microplastic. Nat Commun. 2018;9:1505.
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