Interstitial lung disease occurring shortly after tocilizumab infusion in a patient with polyarticular juvenile idiopathic arthritis: a case report

Author:

Sugihara KoichiORCID,Wakiya Risa,Shimada Hiromi,Kato Mikiya,Kameda Tomohiro,Nakashima Shusaku,Mansour Mai Mahmoud Fahmy,Ushio Yusuke,Kadowaki Norimitsu,Dobashi Hiroaki

Abstract

Abstract Background Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizumab infusion in a patient with JIA. Case presentation A 14-year-old female patient with polyarticular JIA developed interstitial lung disease after intravenous and subcutaneous administration of tocilizumab. Her condition improved with glucocorticoid therapy. Conclusion Our results suggest that increased interleukin-6 levels in the blood following tocilizumab treatment may be linked to development of interstitial lung disease.

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine,Immunology,Immunology and Allergy

Reference21 articles.

1. Mellins ED, Macaubas C, Grom AA. Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions. Nat Rev Rheumatol. 2011;7:416–26.

2. de Jager W, Hoppenreijs EP, Wulffraat NM, Wedderburn LR, Kuis W, Prakken BJ. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis. 2007;66:589–98.

3. Yokota S, Imagawa T, Mori M, et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet. 2008;371:998–1006.

4. Chugai Pharmaceutical Co., Ltd. Final report of all cases of Actemra. Chugai Pharmaceutical Co., Ltd.. 50–55, 2013(in Japanese). https://chugai-pharm.jp/content/dam/chugai/product/act/div/survey/doc/20130723_act_epmpv_safe_ra.pdf. Accessed 22 Dec 2020.

5. Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: Second revision, Edmonton, 2001. J Rheumatol. 2004;31:390–2.

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