Abstract
Abstract
Background
Asthma is considered to be a chronic inflammatory disorder of the airways. Probiotics are living microorganisms that are found in the human gut and have protective effects against a wide range of diseases such as allergies. The aim of this study was to investigate the improvement of clinical asthma symptoms and changes in the expression pattern of selective microRNAs in patients with asthma and the changes in IL-4 and IFN-γ plasma levels after receiving probiotics.
Materials and methods
The present study was a randomized, double-blind, placebo-controlled trial that enrolled 40 asthmatic patients. They were treated with probiotics or placebo: 1 capsule/day for 8 weeks. Pulmonary function tests, IL-4 and IFN-γ levels, and expression of microRNAs were assessed at baseline and after treatment.
Results
The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. In addition, pulmonary function tests showed a significant improvement in Forced Expiratory Volume in 1 s and Forced Vital Capacity after receiving probiotics.
Conclusion
In our study, 8-week treatment with probiotic supplementation led to reduced Th2 cells-associated IL-4 and improved Forced Expiratory Volume and Forced Vital Capacity. It appears probiotics can be used in addition to common asthma treatments.
Funder
Semnan University of Medical Sciences and Health Services
Publisher
Springer Science and Business Media LLC
Subject
Insect Science,Ecology,Ecology, Evolution, Behavior and Systematics
Reference40 articles.
1. Samimi LN, Fallahpour M, Khoshmirsafa M, Moosavi SAJ, Bayati P, Baharlou R, et al. The impact of 17β-estradiol and progesterone therapy on peripheral blood mononuclear cells of asthmatic patients. Mol Biol Rep. 2021;48(1):297–306.
2. Ahmadi-Vasmehjani A, Baharlou R, Atashzar MR, Raofi R, Jafari M, Razavi FS.
Regulatory effects of estradiol on peripheral blood mononuclear cells activation in patients with asthma. Iran J Allergy, Asthma Immunol. 2018;17(1):9–17.
3. Kim H-J, Kim HY, Lee S-Y, Seo J-H, Lee E, Hong S-J. Clinical efficacy and mechanism of probiotics in allergic diseases. Korean J Pediatr. 2013;56(9):369.
4. Foroughi S, Thyagarajan A, Stone KD. Advances in pediatric asthma and atopic dermatitis. Curr Opin Pediatr. 2005;17(5):658–63.
5. Oelschlaeger TA. Mechanisms of probiotic actions–a review. Int J Med Microbiol. 2010;300(1):57–62.
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