Abstract
Abstract
Background
To investigate the associations of lens power with age, axial length (AL), and Type 2 diabetes mellitus (DM) in Chinese adults aged 50 and above.
Methods
Random clustering sampling was used to identify adults aged 50 years and above in urban regions of Shanghai. The participants underwent a comprehensive ophthalmic examination including subjective refraction, autorefraction, and IOL-Master. The crystalline lens power was calculated using Bennett’s formula.
Results
A total of 4177 adults were included. A linear decrease in lens power was observed both with age and with AL, followed by a stop of lens power loss after the age of 70 or when AL ≥ 25 mm, respectively. Participants with Type 2 DM presented higher lens power (0.43 diopter (D), p < 0.001) and thicker lens thickness (0.06 mm, p < 0.001). In multivariate regression models, there was a positive correlation between lens power and Type 2 DM when age < 75 years (p < 0.001) or AL < 25 mm (p < 0.001) after adjusting for other factors, while no significant association was found in participants aged ≥ 75 years (p = 0.122) or with AL ≥ 25 mm (p = 0.172).
Conclusions
The lens power in adults aged 50 and above exhibited two stages with age and with AL. Type 2 DM caused an increase in lens power, which was not seen in participants aged ≥ 75 years or with AL ≥ 25 mm.
Funder
National Natural Science Foundation of China
Public Health Research Programme
Shanghai High-level Overseas Training Team Program on Eye Public Health
Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support
Shanghai General Hosptial, Clinical Research
Science and Technology Commission of Shanghai Municipality
Key Technologies Research and Development Program
National Major Science and Technology Projects of China
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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