Author:
Su Binbin,Zhu Xiaoxuan,Yang Kai,Xiao Yunfan,Li Chunmei,Shi Keai,Qu Jia,Lu Fan,Li Ming,Cui Lele
Abstract
Abstract
Background
To assess age- and sex-related changes in the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in healthy Chinese adults.
Methods
In this cross-sectional study, all data were derived from the community-based Jidong Eye Cohort Study. Participants underwent optical coherence tomography angiography (OCTA) and other ocular and systemic examinations. The vessel densities of the whole measured area, parafovea, and four quadrants in the SCP and DCP were measured.
Results
We recruited 1036 eyes of 1036 healthy participants; the mean age was 40.4 ± 9.8 years, and 449 (43.3%) participants were males. The SCP and DCP vessel densities in all regions, except for temporal and nasal regions in the SCP, non-linearly decreased with age. The DCP vessel densities began to decrease at approximately 35 years of age, while the SCP vessel densities began to decrease at approximately 40 years of age. The DCP vessel densities decreased more rapidly than the SCP vessel densities at 35–50 years of age. The DCP vessel densities remained stable or slightly decreased after the age of 50 years in females, while those decreased linearly in most regions in males.
Conclusions
The retinal vessel density decreased earlier and more rapidly in the DCP than in the SCP, and the effect of aging on the DCP vessel density was sex-dependent. Our findings suggest that age and sex should be considered when interpreting clinical quantitative OCTA data.
Funder
National Natural Science Foundation of China
Zhejiang Provincial Natural Science Foundation of China
National Key R&D Program of China
Wenzhou Science and Technology Program
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology,Health Professions (miscellaneous)
Cited by
3 articles.
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