Abstract
Abstract
Background
The aim of this study was to assess the added value of chemical shift imaging when used with routine MRI study in evaluation of bone marrow changes in SCD. Forty-two patients with SCD and bone pain were included in the study; they underwent CSI and routine MRI study on the symptomatic anatomic part of the skeleton.
Results
Four patterns of diffuse bone marrow changes were recognized; they varied from persistent red marrow to diffuse hypointense patterns with abnormal signal loss percentage on CSI that suggest presence of iron overload (n = 28, 66.6%). Serum ferritin level was increasing in accordance to the degree of signal changes found on CSI with significant high negative correlation between the percentage of signal loss on CSI obtained from IP-OP/IP formula and serum ferritin level. In focal marrow lesions, all T1 hyperintense lesions demonstrated corresponding hyperintensity on IP and OP; the detection frequency on CSI was relatively higher on OP compared with IP images.
Conclusion
CSI has high diagnostic performance in detecting diffuse marrow changes and development of iron overload in SCD. In SCD-related focal marrow lesions, CSI could have a complementary role in detection of T1 hyperintensity and lesion conspicuity.
Publisher
Springer Science and Business Media LLC
Subject
Radiology Nuclear Medicine and imaging
Reference17 articles.
1. Piel FB, Williams TN (2016) Sickle cell anemia: history and epidemiology. In: Costa FF, Conran N (eds) Sickle cell anemia from basic science to clinical practice, vol 2, 1st edn. Springer International Publishing, Switzerland, pp 23–48
2. Patil SN, Veerappa K, Kiran R (2018) Avascular necrosis of the femoral head due to sickle cell disease in tribal population around Vishakhapatnam district, treated with core decompression and non-vascularised fibular graft. Int J Orthop Sci 4(3):672–676
3. Ejindu VC, Hine AL, Mashayekhi M et al (2007) Musculoskeletal manifestations of sickle cell disease. Radiographics 27(4):1005–1021
4. Coates TD, Wood JC (2017) How we manage iron overload in sickle cell patients. Br J Haematol. 177(5):703–716
5. Jain R, Sawhney S, Rizvi SG (2008) Acute bone crises in sickle cell disease: the T1 fat-saturated sequence in differentiation of acute bone infarcts from acute osteomyelitis. Clin Radiol 63(1):59–70
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献