Feasibility of 7-T fluorine magnetic resonance spectroscopic imaging (19F MRSI) for TAS-102 metabolite detection in the liver of patients with metastatic colorectal cancer

Author:

Kurk Sophie A.ORCID,Steensma Bart R.,May Anne M.,Koopman Miriam,Hoogduin Hans M.,van der Velden Tijl A.,Klomp Dennis W. J.,van der Kemp Wybe J. M.

Publisher

Springer Science and Business Media LLC

Subject

Radiology Nuclear Medicine and imaging

Reference20 articles.

1. Miyamoto Y, Lenz H-J, Baba H (2016) A novel antimetabolite: TAS-102 for metastatic colorectal cancer. Expert Rev Clin Pharmacol. 9:355–365

2. Mayer RJ, Van Cutsem E, Falcone A et al (2015) Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 372:1909–1919

3. Van der Velden DL, Opdam FL, Voest EE (2016) TAS-102 for treatment of advanced colorectal cancers that are no longer responding to other therapies. Clin Cancer Res. 22:2835–2840

4. Van Laarhoven HWM, Klomp DWJ, Kamm YJL et al (2003) In vivo monitoring of capecitabine metabolism in human liver by fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength. Cancer Res. 63:7609–7612

5. El-tahtawy A, Wolf W (1991) In vivo measurements of intratumoral metabolism, modulation, and pharmacokinetics of 5-fluorouracil, using 19F nuclear magnetic resonance spectroscopy. Cancer Res. 51:5806–5812

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