Author:
Pasquet Florian,Combarnous François,MacGregor Brigitte,Coppere Brigitte,Mausservey Christelle,Ninet Jacques,Hot Arnaud
Abstract
Abstract
Introduction
Systemic B-cell depletion and clinical remission of the systemic effects of cryoglobulins have already been achieved using rituximab in hepatitis C virus-positive immunocompetent patients. Conversely, to the best of our knowledge there are no reports in the literature regarding the use of rituximab in hepatitis B virus-associated cryoglobulinemia.
Case presentation
We report here the case of a 60-year-old Caucasian man who presented with hepatitis B virus-associated type II cryoglobulinemia with severe multisystem disease, including membranoproliferative glomerulonephritis with acute renal failure. The vasculitis was refractory to conventional and antiviral therapy but rituximab use led to a fall in cryoglobulin levels and disease control. The B-cell depletion was safe and efficient to induce a complete remission of the disease.
Conclusion
Our case highlights the benefit and the efficacy of rituximab in association with antiviral therapy in small vessel vasculitis related to hepatitis B virus-associated mixed cryoglobulinemia.
Publisher
Springer Science and Business Media LLC
Reference15 articles.
1. Ferri C, Zignego AL, Pileri SA: Cryoglobulins. J Clin Pathol. 2002, 55: 4-13. 10.1136/jcp.55.1.4.
2. Ferri C, Antonelli A, Mascia MT, Sebatiani M, Fallahi P, Ferrari D, Pileri SA, Zignego AL: HCV-related autoimmune and neoplastic disorders: the HCV syndrome. Dig Liver Dis. 2007, 39: (Suppl 1):13-21.
3. Galli M, Careddu F, D'Armino A, Monti G, Messina K, Invernizzi F: Hepatitis B virus and essential mixed cryoglobulinaemia. Lancet. 1980, 1: 1093-
4. Levo Y: Hepatitis B virus and essential mixed cryoglobulinemia. Ann Intern Med. 1981, 94: 282-
5. Dienstag JL, Wands JR, Isselbacher KJ: Hepatitis B and essential mixed cryoglobulinemia. N Engl J Med. 1977, 297: 946-947.
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