Author:
Coners Kristin,Woods Scott E,Webb Michael
Abstract
Abstract
Introduction
We describe the case of a patient with small cell lung cancer and dual paraneoplastic syndromes involving adrenocorticotropic hormone and calcitonin. To the best of our knowledge, dual paraneoplastic syndromes involving these two hormones have not been previously reported in the literature.
Case presentation
A 74-year-old Caucasian woman presented with a left hilar mass and metastatic disease in the liver and right adrenal gland. The patient complained only of intermittent diarrhea. Her laboratory values exhibited metabolic alkalosis with hypokalemia, hypocalcemia, hypomagnesemia, hypophosphatemia, and hyperglycemia.
Conclusion
We discuss the work-up and treatment of the patient's unusual laboratory presentation with two concurrent paraneoplastic syndromes.
Publisher
Springer Science and Business Media LLC
Reference12 articles.
1. Gropp C, Havemann K, Scheuer A: Ectopic hormones in lung cancer patients at diagnosis and during therapy. Cancer. 1980, 46: 347-354. 10.1002/1097-0142(19800715)46:2<347::AID-CNCR2820460223>3.0.CO;2-S.
2. Suzuki H, Tsutsumi Y, Yamaguchi K, Abe K, Yokoyama T: Small cell lung carcinoma with ectopic adrenocorticotropic hormone and antidiuretic hormone syndromes: a case report. Jpn J Clin Oncol. 1984, 14: 129-137.
3. Shaker JL, Brickner RC, Divgi AB, Raff H, Findling JW: Case report: renal phosphate wasting, syndrome of inappropriate antidiuretic hormone, and ectopic corticotropin production in small cell carcinoma. Am J Med Sci. 1995, 310: 38-41. 10.1097/00000441-199507000-00011.
4. Pierce ST, Metcalfe M, Banks ER, O'Daniel ME, DeSimone P: Small cell carcinoma with two paraendocrine syndromes. Cancer. 1992, 69: 2258-2261. 10.1002/1097-0142(19920501)69:9<2258::AID-CNCR2820690908>3.0.CO;2-5.
5. Castro Cabezas M, Vrinten DH, Burgers JA, Croughs RJ: Central diabetes insipidus and Cushing's syndrome due to ectopic ACTH production by disseminated small cell lung cancer: a case report. Neth J Med. 1998, 53: 32-36. 10.1016/S0300-2977(98)00051-5.
Cited by
15 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献