Author:
Manikandan Palanisamy,Varga János,Kocsubé Sándor,Revathi Rajaraman,Anita Raghavan,Dóczi Ilona,Németh Tibor Mihály,Narendran Venkatapathy,Vágvölgyi Csaba,Bhaskar Madhavan,Manoharan Chockaiya,Samson Robert A,Kredics László
Abstract
Abstract
Introduction
Human infections caused by Aspergillus brasiliensis have not yet been reported. We describe the first two known cases of fungal keratitis caused by Aspergillus brasiliensis.
Case presentations
A 49-year-old Indian Tamil woman agricultural worker came with pain and defective vision in the right eye for one month. Meanwhile, a 35-year-old Indian Tamil woman presented with a history of a corneal ulcer involving the left eye for 15 days. The fungal strains isolated from these two cases were originally suspected to belong to Aspergillus section Nigri based on macro- and micromorphological characteristics. Molecular identification revealed that both isolates represent A. brasiliensis.
Conclusion
The two A. brasiliensis strains examined in this study were part of six keratitis isolates from Aspergillus section Nigri, suggesting that this recently described species may be responsible for a significant proportion of corneal infections caused by black Aspergilli. The presented cases also indicate that significant differences may occur between the severities of keratitis caused by individual isolates of A. brasiliensis.
Publisher
Springer Science and Business Media LLC
Reference11 articles.
1. Manikandan P, Dóczi I, Kocsubé S, Varga J, Németh TM, Antal Z, Vágvölgyi C, Bhaskar M, Kredics L: Aspergillus species in human keratomycosis. Aspergillus in the genomic era. Edited by: Varga J, Samson R. 2008, Wageningen: Wageningen Academic Publishers, 293-328.
2. Kredics L, Varga J, Kocsubé S, Dóczi I, Samson RA, Rajaraman R, Narendran V, Bhaskar M, Vágvölgyi C, Manikandan P: Case of keratitis caused by Aspergillus tamarii. J Clin Microbiol. 2007, 45: 3464-3467. 10.1128/JCM.00920-07.
3. Varga J, Kocsubé S, Tóth B, Frisvad JC, Perrone G, Susca A, Meijer M, Samson RA: Aspergillus brasiliensis sp. nov., a biseriate black Aspergillus species with world-wide distribution. Int J Syst Evol Microbiol. 2007, 57: 1925-1932. 10.1099/ijs.0.65021-0.
4. National Committee for Clinical Laboratory Standards: Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard. 2002, NCCLS document M38-A. Wayne, PA: National Committee for Clinical Laboratory Standards
5. Chowdhary A, Singh K: Spectrum of fungal keratitis in North India. Cornea. 2005, 24: 8-15. 10.1097/01.ico.0000126435.25751.20.
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