Author:
Hong-Qi Yang,Zhi-Kun Sun,Sheng-Di Chen
Abstract
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs mainly the memory and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau hyperphosphorylation are the two pathological events that are thought to cause neuronal dysfunction in AD. Since the detailed mechanisms that underlie the pathogenesis of AD are still not clear, the current treatments are those drugs that can alleviate the symptoms of AD patients. Recent studies have indicated that these symptom-reliving drugs also have the ability of regulating amyloid precursor protein processing and tau phosphorylation. Thus the pharmacological mechanism of these drugs may be too simply-evaluated. This review summarizes the current status of AD therapy and some potential preclinical considerations that target beta amyloid and tau protein are also discussed.
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neurology (clinical)
Reference66 articles.
1. Farlow M, Veloso F, Moline M, Yardley J, Brand-Schieber E, Bibbiani F, Zou H, Hsu T, Satlin A: Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease. BMC Neurol 2011, 11: 57. 10.1186/1471-2377-11-57
2. Yang HQ, Xing Y: Role of neprilysin in the pathogenesis of Alzheimer’s disease. Prog Biochem Biophys 2012, 39(8):721-725. 10.3724/SP.J.1206.2012.00034
3. Yang HQ, Sun ZK, Zhao YX, Pan J, Ba MW, Lu GQ, Ding JQ, Chen HZ, Chen SD: PMS777, a new cholineraterase inhibitor with anti-platelet activated factor activity activity, regulates amyloid precursor protein processing in vitro. Neurochem Res 2009, 34(3):528-535. 10.1007/s11064-008-9816-4
4. So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR: Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-β precursor protein dimerization. Am J Neurodegener Dis 2012, 1(1):75-87.
5. Wang T, Sun XL: Molecular regulaion of BACE1 and its function at the early onset of Alzheimer’s disease. Prog Biochem Biophys 2012, 39(8):709-714. 10.3724/SP.J.1206.2012.00217
Cited by
70 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献