Author:
Al Ghazal Philipp,Herberger Katharina,Schaller Jörg,Strölin Anke,Hoff Norman-Philipp,Goerge Tobias,Roth Hannelore,Rabe Eberhard,Karrer Sigrid,Renner Regina,Maschke Jan,Horn Thomas,Hepp Julia,Eming Sabine,Wollina Uwe,Zutt Markus,Sick Isabell,Splieth Benno,Dill Dorothea,Klode Joachim,Dissemond Joachim
Abstract
Abstract
Background
Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.
Methods
Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.
Results
We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.
Conclusions
Our study describes one of the world’s largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients’ characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Genetics (clinical),General Medicine
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