Author:
Elbadry Mohammad M.,Tharwat Mina,Mohammad Emad F.,Abdo Ehab F.
Abstract
Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most common cancers and one of the main causes of cancer-related deaths. As the overall survival of patients with cirrhosis has improved and the global incidence of HCC has continued to increase, strategies for the early detection of HCC are urgently needed for better prognosis. In this study, we aimed to assess the accuracy of endothelin-1 in the diagnosis of HCC in cirrhotic patients in comparison with alpha-fetoprotein (AFP) and whether it could predict its vascular spread. This is a case–control study that included 70 cirrhotic patients with or without hepatocellular carcinoma. Patients were subjected to complete medical history taking, clinical examination and laboratory investigations including serum endothelin-1, alpha-fetoprotein, abdominal ultrasound and Triphasic multi-slice computed tomography (CT; abdomen and pelvis). The outcome results obtained for endothelin-1 were used to assess its diagnostic accuracy in HCC diagnosis and the prediction of presence of vascular spread.
Results
There was a statistically significant increase in serum endothelin-1 in HCC in comparison to cirrhotic patients and normal persons (P value < 0.001). Sensitivity, specificity, and positive and negative predictive values at cut-off point of 5.2 pg/ml for HCC were 90%, 100%, 100%, and 90.9% respectively. There was no statistically significant association between serum endothelin-1 level and portal vein thrombosis in HCC (P value = 0.547).
Conclusion
Endothelin-1 has high sensitivity and specificity for diagnosis of hepatocellular carcinoma. However, it has little value for prediction of its vascular spread.
Publisher
Springer Science and Business Media LLC
Reference43 articles.
1. Bertuccio P, Turati F, Carioli G, Rodriguez T et al (2017) Global trends and predictions in hepatocellular carcinoma mortality. J Hepatol 67(2):302–309
2. Goldman R, Ressom HW, Abd el-hamid M et al (2007) Candidate markers for the detection of hepatocellular carcinoma in low molecular weight fraction of serum. Carcinogenesis 28(10):2149–2153
3. Oishi K, Itamoto T, Amano H, Fukuda S et al (2007) Clinico-pathologic features of poorly differentiated hepatocellular carcinoma. J Surg Oncol 95:311–316
4. Maeda T, Shimada M, Harimoto N, Tsujita E et al (2008) Prognosis of early hepatocellular carcinoma after hepatic resection. Hepatogastroenterology 55:1428–1432
5. Bruix J, Sherman M (2005) Diagnosis of small HCC. Gastroenterology 129(4):1364
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