Noninvasive tool for the diagnosis of NAFLD in association with atherosclerotic cardiovascular risk

Abstract

Abstract Background Whether the severity of liver histology in non-alcoholic fatty liver disease (NAFLD) is associated with more pronounced cardiovascular disease is unsettled. There is a need to develop a noninvasive tool to help its diagnosis in association with atherosclerotic cardiovascular disease. We aimed to evaluate the diagnostic performance of NAFLD-liver fat score (NAFLD-LFS) and carotid intima-media thickness (CIMT) in magnetic resonance imaging-proved NAFLD. The study comprised 60 patients with NAFLD during the period from October 2015 to June 2017, diagnosed by clinical features, laboratory tests, and magnetic resonance study. Thirty healthy subjects served as controls. All included individuals were subjected to anthropometric measurements and measurement of NAFLD-LFS and CIMT. Results On doing ultrasonography, 30 cases showed mild, 24 showed moderate, and 6 cases showed severe steatosis. NAFLD-LFS at a cutoff value of − 1.628 showed a sensitivity of 96.7%, specificity 100%, positive predictive value 100%, negative predictive value 93.8%, and accuracy 97.8%. CIMT at a cutoff value of 0.6 had a sensitivity of 70%, specificity 53.3%, positive predictive value 75%, negative predictive value 47.1%, and accuracy 64.4%. The combination of CIMT at cutoff 0.7 and NAFLD-LFS at cutoff − 1.628 showed sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of 100%. Conclusion CIMT combined with NAFLD-LFS can produce a simple noninvasive tool for diagnosis of NAFLD.