Author:
Ståhl Elisabeth,Lindberg Anne,Jansson Sven-Arne,Rönmark Eva,Svensson Klas,Andersson Fredrik,Löfdahl Claes-Göran,Lundbäck Bo
Abstract
Abstract
Background
The aim of this study was to evaluate the association between health-related quality of life (HRQL) and disease severity using lung function measures.
Methods
A survey was performed in subjects with COPD in Sweden. 168 subjects (70 women, mean age 64.3 years) completed the generic HRQL questionnaire, the Short Form 36 (SF-36), the disease-specific HRQL questionnaire; the St George's Respiratory Questionnaire (SGRQ), and the utility measure, the EQ-5D. The subjects were divided into four severity groups according to FEV1 per cent of predicted normal using two clinical guidelines: GOLD and BTS. Age, gender, smoking status and socio-economic group were regarded as confounders.
Results
The COPD severity grades affected the SGRQ Total scores, varying from 25 to 53 (GOLD p = 0.0005) and from 25 to 45 (BTS p = 0.0023). The scores for SF-36 Physical were significantly associated with COPD severity (GOLD p = 0.0059, BTS p = 0.032). No significant association were noticed for the SF-36, Mental Component Summary scores and COPD severity. Scores for EQ-5D VAS varied from 73 to 37 (GOLD I-IV p = 0.0001) and from 73 to 50 (BTS 0-III p = 0.0007). The SGRQ Total score was significant between age groups (p = 0.0047). No significant differences in HRQL with regard to gender, smoking status or socio-economic group were noticed.
Conclusion
The results show that HRQL in COPD deteriorates with disease severity and with age. These data show a relationship between HRQL and disease severity obtained by lung function.
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health,General Medicine
Reference32 articles.
1. Vollmer WM, Osborne ML, Buist AS: 20-year trends in the prevalence of asthma and chronic airflow obstruction in an HMO. American Journal of Respiratory & Critical Care Medicine 1998, 157: 1079–1084.
2. Pauwels RA, Buist AS, Calverley PMA, Jenkins CR, Hurd SS: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI and WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. Respiratory Care 2001, 46: 798–825.
3. BTS: BTS guidelines for the management of chronic obstructive pulmonary disease. The COPD Guidelines Group of the Standards of Care Committee of the BTS. Thorax 1997, 52: S1–28.
4. Ray D, Abel R, Selvaraj KG: A 5-yr prospective epidemiological study of chronic obstructive pulmonary disease in rural south India. Indian Journal of Medical Research 1995, 101: 238–244.
5. Renwick DS, Connolly MJ: Prevalence and treatment of chronic airways obstruction in adults over the age of 45. Thorax 1996, 51: 164–168.
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