Identification of canine parvovirus with the Q370R point mutation in the VP2 gene from a giant panda (Ailuropoda melanoleuca)

Author:

Guo Ling,Yang Shao-lin,Chen Shi-jie,Zhang Zhihe,Wang Chengdong,Hou Rong,Ren Yupeng,wen Xintian,Cao Sanjie,Guo Wanzhu,Hao Zhongxiang,Quan Zifang,Zhang Manli,Yan Qi-gui

Abstract

Abstract Background In this study, we sequenced and phylogenetic analyses of the VP2 genes from twelve canine parvovirus (CPV) strains obtained from eleven domestic dogs and a giant panda (Ailuropoda melanoleuca) in China. A novel canine parvovirus (CPV) was detected from the giant panda in China. Results Nucleotide and phylogenetic analysis of the capsid protein VP2 gene classified the CPV as a new CPV-2a type. Substitution of Gln for Arg at the conserved 370 residue in CPV presents an unusual variation in the new CPV-2a amino acid sequence of the giant panda and is further evidence for the continuing evolution of the virus. Conclusions These findings extend the knowledge on CPV molecular epidemiology of particular relevance to wild carnivores.

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Virology

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