Author:
Lin Wenyao,Fan Huiying,Cheng Xiaoliang,Ye Yu,Chen Xiaowei,Ren Tao,Qi Wenbao,Liao Ming
Abstract
Abstract
Background
Avian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to devise protective strategies against them.
Results
The results showed that stronger immune responses were induced in a mouse model immunized with BV-Dual-HA than in those vaccinated with a DNA vaccine encoding the same antigen. Moreover, complete protection against lethal challenge with H9N2 virus was observed in mice.
Conclusion
BV-Dual-HA could be utilized as a vaccine candidate against H9N2 virus infection.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
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