Author:
Zeng Jun,Wang Gefei,Li Weizhong,Zhang Dangui,Chen Xiaoxuan,Xin Gang,Jiang Zhiwu,Li Kangsheng
Abstract
Abstract
Background
Coxsackievirus commonly infects children and occasionally causes severe meningitis and/or encephalitis in the newborn. The underlying mechanism(s) behind the central nervous system pathology is poorly defined.
Methods
It is hypothesized that astrocytes may be involved in inflammatory response induced by CVB3 infection. Here we discuss this hypothesis in the context of CVB3 infection and associated inflammatory response in primary mouse astrocytes.
Results
The results showed that coxsackievirus receptor (CAR) was distributed homogeneously on the astrocytes, and that CVB3 could infect and replicate in astrocytes, with release of infectious virus particles. CVB3 induced cytopathic effect and production of proinflammatory cytokines IL-1β, TNF-α, IL-6, and chemokine CXCL10 from astrocytes.
Conclusion
These data suggest that direct astrocyte damage and cytokines induction could be a mechanism of virus-induced meningitis and/or encephalitis.
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
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