Evaluation of a low-cost, portable imaging system for early detection of oral cancer

Author:

Rahman Mohammed S,Ingole Nilesh,Roblyer Darren,Stepanek Vanda,Richards-Kortum Rebecca,Gillenwater Ann,Shastri Surendra,Chaturvedi Pankaj

Abstract

Abstract Background There is an important global need to improve early detection of oral cancer. Recent reports suggest that optical imaging technologies can aid in the identification of neoplastic lesions in the oral cavity; however, there is little data evaluating the use of optical imaging modalities in resource limited settings where oral cancer impacts patients disproportionately. In this article, we evaluate a simple, low-cost optical imaging system that is designed for early detection of oral cancer in resource limited settings. We report results of a clinical study conducted at Tata Memorial Hospital (TMH) in Mumbai, India using this system as a tool to improve detection of oral cancer and its precursors. Methods Reflectance images with white light illumination and fluorescence images with 455 nm excitation were obtained from 261 sites in the oral cavity from 76 patients and 90 sites in the oral cavity from 33 normal volunteers. Quantitative image features were used to develop classification algorithms to identify neoplastic tissue, using clinical diagnosis of expert observers as the gold standard. Results Using the ratio of red to green autofluorescence, the algorithm identified tissues judged clinically to be cancer or clinically suspicious for neoplasia with a sensitivity of 90% and a specificity of 87%. Conclusions Results suggest that the performance of this simple, objective low-cost system has potential to improve oral screening efforts, especially in low-resource settings.

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Otorhinolaryngology

Reference24 articles.

1. American Cancer Society: Cancer Facts and Figures. 2005

2. Ferlay J, Parkin DM, Pisani P: GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. 2004, IARC Scientific Publication, 5:

3. Sankaranarayanan R, Black RJ, Parkin DM: Cancer survival in developing countries. 1998, IARC Scientific Publication, 145:

4. Lingen MW, Kalmar JR, Karrison T, Speight Paul: Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncology. 2008, 44: 10-22. 10.1016/j.oraloncology.2007.06.011.

5. Lane PM, Gilhuly T, Whitehead P, Zeng H, Poh CF, Ng S, Williams PM, Zhang L, Rosin MP, MacAulay CE: Simple device for the direct visualization of oral-cavity tissue fluorescence. J of Biomed Optics. 2006, 11 (2): 24006-10.1117/1.2193157.

Cited by 50 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3