Hypoglycemia associated with L-asparaginase in acute lymphoblastic leukemia treatment: a case report-Reference-Cited by-同舟云学术

Hypoglycemia associated with L-asparaginase in acute lymphoblastic leukemia treatment: a case report

Published:2012-04-19 Issue:1 Volume:1 Page:
ISSN:2162-3619
Container-title:Experimental Hematology & Oncology
language:en
Short-container-title:Exp Hematol Oncol

Author:

Tanaka Ryuma,Osumi Tomoo,Miharu Masashi,Ishii Tomohiro,Hasegawa Tomonobu,Takahashi Takao,Shimada Hiroyuki

Abstract

Abstract A patient with acute lymphoblastic leukemia repeatedly developed hypoglycemia during chemotherapy. Comparison of serum glucose trends between chemotherapy with and without L-asparaginase (L-Asp) demonstrated a strong association between L-Asp and hypoglycemia. Critical blood sampling during hypoglycemia indicated hyperinsulinism, suggesting that L-Asp induced hypoglycemia in the patient through inappropriate insulin secretion. Identification of hypoglycemia as an adverse effect will enable clinicians to understand and develop appropriate strategies for L-Asp use in chemotherapy regimens.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Hematology

Link

https://link.springer.com/content/pdf/10.1186/2162-3619-1-8.pdf

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