Abstract
AbstractInfrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive neural modulation modality. Optical nanoparticles with the absorption in the near-infrared (NIR) window have emerged as excellent photothermal transducers due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency and limited stimulation depth are main predicaments encountered in the neural stimulation mediated by these nanoparticles. In this study, we prepared a targeted polydopamine (PDA)-coated gold (Au) nanoparticles with specific binding to thermo-sensitive ion channel as nanotransducers for second near-infrared (NIR-II) photo-stimulation of neurons in rats. The targeted Au nanoparticles were constructed via conjugation of anti-TRPV1 antibody with PEGylated PDA-coated Au nanoparticles and thus exhibited potent photothermal performance property in the second NIR (NIR-II) window and converted NIR-II light to heat to rapidly activate Ca2+ influx of neurons in vitro. Furthermore, wireless photothermal stimulation of neurons in living rat successfully evoke excitation in neurons in the targeted brain region as deep as 5 mm beneath cortex. This study thus demonstrates a remote-controlled strategy for neuromodulation using photothermal nanotransducers.
Funder
Postdoctoral Research Foundation of China
Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
Fundamental Research Funds for the Central Universities
Science and Technology Commission of Shanghai Municipality
Publisher
Springer Science and Business Media LLC
Subject
General Engineering,General Materials Science
Reference55 articles.
1. S.L. Moshe, E. Perucca, P. Ryvlin, T. Tomson, Epilepsy: new advances. Lancet 385(9971), 884–898 (2015)
2. J.S. Brittain, H. Cagnan, Recent trends in the use of electrical neuromodulation in Parkinson’s disease. Curr. Neurol. Neurosci. Rep. 5(2), 170–178 (2018)
3. A. Vlaicu, M.B. Vlaicu, New neuromodulation techniques for treatment resistant depression. Int. J. Psychiatry Clin. Pract. 24(2), 106–115 (2020)
4. J.K. Krauss, N. Lipsman, T. Aziz, A. Boutet, P. Brown, J.W. Chang, B. Davidson, W.M. Grill, M.I. Hariz, A. Horn, M. Schulder, A. Mammis, P.A. Tass, J. Volkmann, A.M. Lozano, Technology of deep brain stimulation: current status and future directions. Nat. Rev. Neurol. 17(2), 75–87 (2021)
5. D. Atasoy, S.M. Sternson, Chemogenetic tools for causal cellular and neuronal biology. Physiol. Rev. 98(1), 391–418 (2018)
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献