Antibody-conjugated gold nanoparticles as nanotransducers for second near-infrared photo-stimulation of neurons in rats

Author:

Liu Jiansheng,Li Jiajia,Zhang Shu,Ding Mengbin,Yu Ningyue,Li JingchaoORCID,Wang Xiuhui,Li Zhaohui

Abstract

AbstractInfrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive neural modulation modality. Optical nanoparticles with the absorption in the near-infrared (NIR) window have emerged as excellent photothermal transducers due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency and limited stimulation depth are main predicaments encountered in the neural stimulation mediated by these nanoparticles. In this study, we prepared a targeted polydopamine (PDA)-coated gold (Au) nanoparticles with specific binding to thermo-sensitive ion channel as nanotransducers for second near-infrared (NIR-II) photo-stimulation of neurons in rats. The targeted Au nanoparticles were constructed via conjugation of anti-TRPV1 antibody with PEGylated PDA-coated Au nanoparticles and thus exhibited potent photothermal performance property in the second NIR (NIR-II) window and converted NIR-II light to heat to rapidly activate Ca2+ influx of neurons in vitro. Furthermore, wireless photothermal stimulation of neurons in living rat successfully evoke excitation in neurons in the targeted brain region as deep as 5 mm beneath cortex. This study thus demonstrates a remote-controlled strategy for neuromodulation using photothermal nanotransducers.

Funder

Postdoctoral Research Foundation of China

Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

Fundamental Research Funds for the Central Universities

Science and Technology Commission of Shanghai Municipality

Publisher

Springer Science and Business Media LLC

Subject

General Engineering,General Materials Science

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