Microfluidics for disease diagnostics based on surface-enhanced raman scattering detection

Author:

Yu Xiangdong,Park Sohyun,Lee Sungwoon,Joo Sang-Woo,Choo JaebumORCID

Abstract

AbstractThis review reports diverse microfluidic systems utilizing surface-enhanced Raman scattering (SERS) detection for disease diagnosis. Integrating SERS detection technology, providing high-sensitivity detection, and microfluidic technology for manipulating small liquid samples in microdevices has expanded the analytical capabilities previously confined to larger settings. This study explores the principles and uses of various SERS-based microfluidic devices developed over the last two decades. Specifically, we investigate the operational principles of documented SERS-based microfluidic devices, including continuous-flow channels, microarray-embedded microfluidic channels, droplet microfluidic channels, digital droplet channels, and gradient microfluidic channels. We also examine their applications in biomedical diagnostics. In conclusion, we summarize the areas requiring further development to translate these SERS-based microfluidic technologies into practical applications in clinical diagnostics.

Funder

National Research Foundation of Korea

Chung-Ang University Graduate Research Scholarship

Publisher

Springer Science and Business Media LLC

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