Violence and post-traumatic stress disorder in Sao Paulo and Rio de Janeiro, Brazil: the protocol for an epidemiological and genetic survey

Author:

Andreoli Sérgio Baxter,Ribeiro Wagner Silva,Quintana Maria Ines,Guindalini Camila,Breen Gerome,Blay Sergio Luis,Coutinho Evandro SF,Harpham Trudy,Jorge Miguel Roberto,Lara Diogo Rizzato,Moriyama Tais S,Quarantini Lucas C,Gadelha Ary,Vilete Liliane Maria Pereira,Yeh Mary SL,Prince Martin,Figueira Ivan,Bressan Rodrigo A,Mello Marcelo F,Dewey Michael E,Ferri Cleusa P,Mari Jair de Jesus

Abstract

Abstract Background violence is a public health major concern, and it is associated with post-traumatic stress disorder and other psychiatric outcomes. Brazil is one of the most violent countries in the world, and has an extreme social inequality. Research on the association between violence and mental health may support public health policy and thus reduce the burden of disease attributable to violence. The main objectives of this project were: to study the association between violence and mental disorders in the Brazilian population; to estimate the prevalence rates of exposure to violence, post-traumatic stress disorder, common metal disorder, and alcohol hazardous use and dependence: and to identify contextual and individual factors, including genetic factors, associated with the outcomes. Methods/design one phase cross-sectional survey carried out in Sao Paulo and Rio de Janeiro, Brazil. A multistage probability to size sampling scheme was performed in order to select the participants (3000 and 1500 respectively). The cities were stratified according to homicide rates, and in Sao Paulo the three most violent strata were oversampled. The measurements included exposure to traumatic events, psychiatric diagnoses (CIDI 2.1), contextual (homicide rates and social indicators), and individual factors, such as demographics, social capital, resilience, help seeking behaviours. The interviews were carried between June/2007 February/2008, by a team of lay interviewers. The statistical analyses will be weight-adjusted in order to take account of the design effects. Standardization will be used in order to compare the results between the two centres. Whole genome association analysis will be performed on the 1 million SNP (single nucleotide polymorphism) arrays, and additional association analysis will be performed on additional phenotypes. The Ethical Committee of the Federal University of Sao Paulo approved the study, and participants who matched diagnostic criteria have been offered a referral to outpatient clinics at the Federal University of Sao Paulo and Federal University of Rio de Janeiro.

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

Reference60 articles.

1. Guerrero R: Violence is a health issue. Bulletin of the World Health Organization. 2002, 80: 767-

2. Krug EG, Dahlberg LL, Mercy JA, Zwi AB, Lozano R: World report on violence and health. 2002, Geneva: World Health Organization

3. Rutherford A, Zwi AB, Grove NJ, Butchart A: Violence: a priority for public health? (part 2). J Epidemiol Community Health. 2007, 61 (9): 764-70. 10.1136/jech.2006.049072.

4. PAHO: Health situation in the americas: basic indicators. 2005, Washington, DC: Pan American Health Organization

5. Concha-Eastman A: Violence: a challenge for public health and for all. J Epidemiol Community Health. 2001, 55 (8): 597-9. 10.1136/jech.55.8.597.

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