Author:
Al-Salahi Rashad,El-Tahir Kamal-Eldin,Alswaidan Ibrahim,Lolak Nabih,Hamidaddin Mohammed,Marzouk Mohamed
Abstract
Abstract
Background
Several quinazoline and triazole derivatives are reported to possess a wide-range of interesting pharmacological effects. Although various triazoloquinazoline subclasses having been synthesized and studied, the preparation of 1,2,4-triazolo[1,5-a]quinazolines as antihypertensive agent is still relatively unexplored. In continuation of our earlier research, we aimed at the synthesis and development of various potent antihypertensive 1,2,4-triazoloquinazoline derivatives.
Results
A new series of 1,2,4-triazolo[1,5-a]quinazoline derivatives have been synthesized. Their structures were mainly established by spectroscopic methods of analysis (IR, MS, 1H and 13C NMR). Their in vivo antihypertensive activity was evaluated by tail cuff method using Muromachi Blood Pressure Monitor (Model MK 2000) for rats and mice. Some of the tested compounds were found to exhibit valuable effects in terms of heart rate and blood pressure. According to the biological results, some of tested derivatives have abolished completely the tachycardia of the parent compounds and may be studied and modified as potential adrenoblockers and cardiac stimulant.
Conclusion
New series of fifteen 1,2,4-triazolo[1,5-a]quinazolines were synthesized by convenient methodology from four key molecules, whereby their structures were established by advanced spectroscopic analyses. Some lead compounds have abolished completely the tachycardia of the parent compounds, that may be examined as potent adrenoblockers and some other compounds seem to be a cardiac stimulant or may be modified to enhance their hypotensive activity.
Publisher
Springer Science and Business Media LLC
Reference20 articles.
1. Alagarsamy V, Pathak US: Synthesis and antihypertensive activity of novel 3-benzyl-2-substituted 3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones. Bioorg Med Chem. 2007, 15: 3457-3462. 10.1016/j.bmc.2007.03.007.
2. Garcia DJ, Somanathan R, Rivero IA, Aguirre G, Hellberg LH: Synthesis of deuterium-labeled antihypertensive 3-(4-Phenyl-1′-Piperazinyl)-Propyl-2,4-quinazolinedione. Synth Commun. 2000, 30: 2707-2711. 10.1080/00397910008086895.
3. Alagarsamy V, Venkatesaperumal R, Vijayakumar S, Angayarkanni T, Pounammal P, Senthilganesh S, Kandeeban S: Synthesis and pharmacological investigation of some novel 2-phenyl-3-(substituted methyl amino) quinazolin-4(3 h)-ones as h1-receptor blockers. Pharmazie. 2002, 57: 306-307.
4. Alagarsamy V: Synthesis and pharmacological investigation of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones as histamine H1 receptor blockers. Pharmazie. 2004, 59: 753-755.
5. Alagarsamy V, Solomon VR, Vanikavitha G, Paluchamy V, Ravichandran M, Arnaldsujin A, Thangathirupathy A, Amuthalakshmi S, Revathi R: Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones. Biol Pharm Bull. 2002, 25: 1432-1435. 10.1248/bpb.25.1432.
Cited by
31 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献