Author:
Obistioiu Diana,Cristina Romeo T,Schmerold Ivo,Chizzola Remigius,Stolze Klaus,Nichita Ileana,Chiurciu Viorica
Abstract
Abstract
Background
A large number of essential oils is reported to have significant activity against Candida albicans. But the different chemical composition influences the degree of their activity. The intention of this study was to investigate the chemical composition and the activity against Candida albicans of volatile oils obtained from Artemisia dracunculus, A. abrotanum, A. absinthium and A. vulgaris (Asteraceae). The aim of the study was to identify new chemical compounds that have effect against C. albicans.
The essential oils were obtained by hydrodistillation or extraction with dichloromethane (a new procedure we developed trying to obtain better, more separated compounds) from air dried above ground plant material and analyzed by GC-MS. Additionally commercial essential oils from the same species were tested. The Candida albicans inhibition studies were carried out by the paper disc diffusion method.
Results
The essential oils shared common components but presented differences in composition and showed variable antifungal activity. Davanone and derivatives thereof, compounds with silphiperfolane skeleton, estragole, davanone oil, β-thujone, sabinyl acetate, herniarin, cis-chrysanthenyl acetate, 1,8-cineol, and terpineol were the main components of Artemisia volatiles.
Conclusions
Among the volatile fractions tested those from A. abrotanum containing davanone or silphiperfolane derivatives showed the highest antifungal activity. The in vitro tests revealed that the Artemisia oils are promising candidates for further research to develop novel anti-candida drugs.
Publisher
Springer Science and Business Media LLC
Reference42 articles.
1. Hayat MQ, Ashraf M, Khan MA, Jabeen S: Ethnobotany of the genus Artemisia L. (Asteraceae) in Pakistan. Ethnobot Res Appl. 2009, 7: 147-162.
2. Hayat MQ, Ashraf M, Khan MA, Yasmin G, Shaheen N, Jabeen S: Palynological study of the Genus Artemisia (Asteraceae) and its systematic implications. Pak J Bot. 2010, 42 (2): 751-763.
3. Pareto G: Artemisie. Ricerca ed applicazione. Q. Agric. Suppl. 1985, 2: 1-261.
4. Tan RX, Zheng WF, Tang HQ: Biologically active substances from the genus Artemisia. Planta Med. 1998, 64: 295-302. 10.1055/s-2006-957438.
5. Blagojevic P, Radulovic N, Palic R, Stojanovic G: Chemical composition of the essential oils of serbian wild-growing Artemisia absinthium and Artemisia vulgaris. J Agric Food Chem. 2006, 54: 4780-4789. 10.1021/jf060123o.
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